Document Detail

Gastric acid secretion and water balance in the marine teleost Gadus morhua.
MedLine Citation:
PMID:  420016     Owner:  NLM     Status:  MEDLINE    
Gastric acid secretion was measured in unanaesthetized codfish surgically equipped with a catheter draining the stomach. The pylorus was ligated. Without perfusion of the intestine, or during perfusion with pure sea water (100% SW) or slightly diluted (67%) SW, gastric acid secretion was low ( less than 10 mumol H+/kg.h) and the fishes became dehydrated during the experiment. Perfusion of the intestine with 50% or 3% SW enabled the fishes to compensate for the water loss to the environment and greatly enhanced gastric acid secretion. Acid secretion was elevated also in fishes in which the dehydration was prevented by an intra-muscular infusion of saline. Perfusion of the intestine (8.5 ml/h) decreased the hourly effluent volume ('drinking rate') from the stomach to almost zero within 2 h. The effect was independent of the degree of dilution of the perfusing SW, but was less pronounced when the perfusion rate was lowered. Intra-muscular saline also depressed 'drinking rate'. The acid secretion prevailing during perfusion of the intestine with SW at a dilution preventing dehydration--suggested to represent the basal acid secretion of the codfish--was inhibited by atropine, hexamethonium, and metiamide.
B Holstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  105     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-04-25     Completed Date:  1979-04-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  93-107     Citation Subset:  IM    
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MeSH Terms
Atropine / pharmacology
Dehydration / etiology
Fishes / physiology*
Gastric Acidity Determination
Gastric Juice / secretion*
Hexamethonium Compounds / pharmacology
Intestines / physiology
Metiamide / pharmacology
Phenolsulfonphthalein / metabolism
Secretory Rate / drug effects
Sodium Chloride / pharmacology
Water-Electrolyte Balance* / drug effects
Reg. No./Substance:
0/Hexamethonium Compounds; 143-74-8/Phenolsulfonphthalein; 34839-70-8/Metiamide; 51-55-8/Atropine; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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