| Gastric acid secretion and water balance in the marine teleost Gadus morhua. | |
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MedLine Citation:
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PMID: 420016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastric acid secretion was measured in unanaesthetized codfish surgically equipped with a catheter draining the stomach. The pylorus was ligated. Without perfusion of the intestine, or during perfusion with pure sea water (100% SW) or slightly diluted (67%) SW, gastric acid secretion was low ( less than 10 mumol H+/kg.h) and the fishes became dehydrated during the experiment. Perfusion of the intestine with 50% or 3% SW enabled the fishes to compensate for the water loss to the environment and greatly enhanced gastric acid secretion. Acid secretion was elevated also in fishes in which the dehydration was prevented by an intra-muscular infusion of saline. Perfusion of the intestine (8.5 ml/h) decreased the hourly effluent volume ('drinking rate') from the stomach to almost zero within 2 h. The effect was independent of the degree of dilution of the perfusing SW, but was less pronounced when the perfusion rate was lowered. Intra-muscular saline also depressed 'drinking rate'. The acid secretion prevailing during perfusion of the intestine with SW at a dilution preventing dehydration--suggested to represent the basal acid secretion of the codfish--was inhibited by atropine, hexamethonium, and metiamide. |
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Authors:
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B Holstein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta physiologica Scandinavica Volume: 105 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 1979 Jan |
Date Detail:
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Created Date: 1979-04-25 Completed Date: 1979-04-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 93-107 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology Catheterization Dehydration / etiology Female Fishes / physiology* Gastric Acidity Determination Gastric Juice / secretion* Hexamethonium Compounds / pharmacology Intestines / physiology Male Metiamide / pharmacology Perfusion Phenolsulfonphthalein / metabolism Seawater Secretory Rate / drug effects Sodium Chloride / pharmacology Water-Electrolyte Balance* / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Hexamethonium Compounds; 143-74-8/Phenolsulfonphthalein; 34839-70-8/Metiamide; 51-55-8/Atropine; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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