Document Detail

Gastric acid secretion induced by paraventricular nucleus microinjection of orexin A is mediated through activation of neuropeptide Yergic system.
MedLine Citation:
PMID:  22986171     Owner:  NLM     Status:  MEDLINE    
KEY RESULTS: ICV microinjections of GR-231118 and CGP-71683 decreased acid secretion by 25±0.05% and 67±0.02%, respectively. ICV microinjections of GR-231118 and CGP-71683 inhibited effects of PVN-injected orexin-A on acid secretion. We suggest that Y1 and Y5 receptors stimulate gastric acid secretion and the stimulatory effect of PVN orexin receptors on gastric acid secretion may be mediated via interactions, at least in part, through activation of Y1 and Y5 receptors. These neural pathways may play key roles in the orexinergic action of orexins in the cephalic phase of gastric acid secretion.
M Kermani; A Eliassi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-15
Journal Detail:
Title:  Neuroscience     Volume:  226     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-05     Completed Date:  2013-04-22     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Gastric Acid / secretion*
Gastric Juice / secretion
Intracellular Signaling Peptides and Proteins / administration & dosage,  pharmacology*
Naphthalenes / administration & dosage,  pharmacology
Neuropeptide Y / antagonists & inhibitors,  physiology*
Neuropeptides / administration & dosage,  pharmacology*
Paraventricular Hypothalamic Nucleus / drug effects*
Peptides, Cyclic / administration & dosage,  pharmacology
Pyrimidines / administration & dosage,  pharmacology
Rats, Wistar
Receptors, G-Protein-Coupled / antagonists & inhibitors,  drug effects
Receptors, Neuropeptide / antagonists & inhibitors,  drug effects
Receptors, Neuropeptide Y / antagonists & inhibitors,  drug effects
Reg. No./Substance:
0/1229U91; 0/CGP 71683 A; 0/Intracellular Signaling Peptides and Proteins; 0/Naphthalenes; 0/Neuropeptide Y; 0/Neuropeptides; 0/Npy1r protein, rat; 0/Peptides, Cyclic; 0/Pyrimidines; 0/Receptors, G-Protein-Coupled; 0/Receptors, Neuropeptide; 0/Receptors, Neuropeptide Y; 0/neuropeptide Y5 receptor; 0/orexins

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