Document Detail


Gastric acid secretion in the cynomolgus monkey.
MedLine Citation:
PMID:  7844955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gastric acid secretion was measured in male and female cynomolgus monkeys under basal conditions and in response to intravenous administration of pentagastrin (PG). There were no statistically significant differences between males and females in either basal or PG-stimulated gastric acid output. Neither were differences between males and females statistically significant when adjusted according to body weight. For both sexes combined, basal acid output was 17 +/- 20 muEq/h. Intravenous infusion of PG stimulated gastric acid secretion at dose rates of 1 micrograms/kg/h and greater. Maximal stimulation occurred at dose rates of 10 and 100 micrograms/kg/h, indicating gastric acid secretion plateaus above PG doses of 10 micrograms/kg. Acid secretion values in response to 100 micrograms of PG/kg/h for both sexes combined were 571 +/- 132 and 400 +/- 135 muEq/kg/h for peak acid output and maximum acid output, respectively. These data suggest that the cynomolgus monkey may be a useful model for gastric physiology studies of relevance to human beings.
Authors:
L A Dethloff; D M Altrogge; K A Gillhouse
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory animal science     Volume:  44     ISSN:  0023-6764     ISO Abbreviation:  Lab. Anim. Sci.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-03-03     Completed Date:  1995-03-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1266503     Medline TA:  Lab Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  468-71     Citation Subset:  IM    
Affiliation:
Department of Pathology and Experimental Toxicology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48104.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Dose-Response Relationship, Drug
Female
Gastric Acid / secretion*
Macaca fascicularis / physiology*
Male
Pentagastrin / administration & dosage,  diagnostic use
Reference Values
Sex Characteristics
Chemical
Reg. No./Substance:
5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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