Document Detail

Gastric acid secretion and gastroduodenal pH after pancreaticogastrostomy in dogs.
MedLine Citation:
PMID:  8769959     Owner:  NLM     Status:  MEDLINE    
Pancreaticogastrostomy has been reintroduced as a useful alternative procedure to pancreaticojejunostomy after Whipple resection or pylorus-preserving pancreaticoduodenectomy because of the very low incidence of leakage and disruption. In this study, gastric acid secretion, serum gastrin level, and 24-hr dual gastroduodenal pH after pancreaticogastrostomy were examined on the assumption that a canine model was a pylorus-preserving pancreaticoduodenectomy. Basal acid output (BAO), maximal acid output (MAO), and dual gastroduodenal pH were measured in eight dogs with gastric fistula. After pancreaticogastrostomy, BAO levels showed a slight increase significantly, but MAO levels showed no change. Serum gastrin levels in the fasting and postprandial states showed the similar patterns between before and after surgery. In the 24-hr dual gastroduodenal pH monitoring, gastric pH and duodenal pH also did not change in the fasting and postprandial states. These results suggested that the maintenance of the normal gastric pH after pancreaticogastrostomy was caused by a little increase of BAO, and the neurohumoral relationship between the stomach, duodenum, and pancreas was preserved even after pancreaticogastrostomy. Therefore, the pancreaticogastrostomy is a recommendable reconstructive procedure physiologically after pylorus-preserving pancreaticoduodenectomy.
H Shinchi; S Takao; K Fukura; T Aikou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of surgical research     Volume:  61     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-12-30     Completed Date:  1996-12-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  152-8     Citation Subset:  IM    
First Department of Surgery, Kagoshima University School of Medicine, Japan.
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MeSH Terms
Anastomosis, Surgical*
Duodenum / metabolism*
Gastric Acid / secretion*
Gastrins / blood
Hydrogen / metabolism
Hydrogen-Ion Concentration
Monitoring, Physiologic
Pancreas / surgery*
Stomach / metabolism*,  surgery*
Reg. No./Substance:
0/Gastrins; 1333-74-0/Hydrogen

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