Document Detail


Gastric acid response to antrum distension in man.
MedLine Citation:
PMID:  235787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gastric acid secretion under basal conditions and in response to graded balloon distension (50 ml, 100 ml, 150 ml) of the antrum was determined in healthy subjects and in peptic ulcer patients. In patients with a quiescent duodenal ulcer or a gastric ulcer antrum distension produced slight acid responses. The acid response to antrum distension was of quantitative importance only in patients with an active duodenal ulcer, amounting to 35 percent of the maximal acid response to pentagastrin. The healthy subjects did not respond with acid secretion to antrum distension. The pH of the gastric contents in the present series was 1.8-3.0, being lowest in patients with an active duodenal ulcer. Thus, the acid secretory effect of mechanical stimulation of the antrum seems qualitatively different in healthy subjects and ulcer patients, with a marked acid response in patients with an active duodenal ulcer.
Authors:
S Bergegårdh; L Olbe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  10     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1975  
Date Detail:
Created Date:  1975-07-07     Completed Date:  1975-07-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  171-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Duodenal Ulcer / metabolism
Female
Gastric Acidity Determination
Gastric Juice / secretion*
Humans
Hydrogen-Ion Concentration
Male
Middle Aged
Pentagastrin / pharmacology
Pyloric Antrum* / physiology
Secretory Rate / drug effects
Stimulation, Chemical
Stomach Ulcer / metabolism
Chemical
Reg. No./Substance:
5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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