Document Detail

Gastric acid reduction leads to an alteration in lower intestinal microflora.
MedLine Citation:
PMID:  19248769     Owner:  NLM     Status:  MEDLINE    
To clarify the alterations in lower intestinal microflora induced by gastric acid reduction, the dynamics of 12 major genera or groups of bacteria comprising the microflora in feces and colonic contents were examined by quantitative real-time PCR in proton pump inhibitor-treated rats and in asymptomatic human subjects with hypochlorhydria. In both rat and human experiments, most genera or groups of intestinal microflora (facultative and obligate anaerobes) proliferated by gastric acid reduction, and marked and significant increases in the Lactobacilli group and Veillonella, oropharyngeal bacteria, were observed. In rats, potent gastric acid inhibition led to a marked and significant increase of intestinal bacteria, including the Bacteroidesfragilis group, while Bifidobacterium, a beneficial bacterial species, remained at a constant level. These results strongly indicate that the gastric acid barrier not only controls the colonization and growth of oropharyngeal bacteria, but also regulates the population and composition of lower intestinal microflora.
Takayuki Kanno; Takahiro Matsuki; Masashi Oka; Hirotoshi Utsunomiya; Kenichi Inada; Hirohito Magari; Izumi Inoue; Takao Maekita; Kazuki Ueda; Shotaro Enomoto; Mikitaka Iguchi; Kimihiko Yanaoka; Hideyuki Tamai; Shigeru Akimoto; Koji Nomoto; Ryuichiro Tanaka; Masao Ichinose
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-25
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  381     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  666-70     Citation Subset:  IM    
Department of Gastroenterology, Wakayama Medical University, Japan.
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MeSH Terms
Bacteria / classification*,  isolation & purification
Colon / microbiology*
Gastric Acid / secretion*
Middle Aged
Rats, Wistar

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