Document Detail


Gastric peptides and their regulation of hunger and satiety.
MedLine Citation:
PMID:  23001831     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ingestion of food affects the secretion of hormones from specialized endocrine cells scattered within the intestinal mucosa. Upon release, these hormones mostly decrease food intake by signaling information to the brain. Although enteroendocrine cells in the small intestine were thought to represent the predominant gut-brain regulators of food intake, recent advances also established a major role for gastric hormones in these regulatory pathways. First and foremost, the gastric endocrine X/A-like cell was in the focus of many studies due to the production of ghrelin, which is until now the only known orexigenic hormone that is peripherally produced and centrally acting. Although X/A-cells were initially thought to only release one hormone that stimulates food intake, this view has changed with the identification of additional peptide products also derived from this cell, namely desacyl ghrelin, obestatin, and nesfatin-1. Desacyl ghrelin may play a counter-regulatory role to the food intake stimulatory effect of ghrelin. The same property was suggested for obestatin; however, this hypothesis could not be confirmed in numerous subsequent studies. Moreover, the description of the stomach as the major source of the novel anorexigenic hormone nesfatin-1 derived from the NUCB2 gene further corroborated the assumption that the gastric X/A-like cell products are not only stimulant but also inhibitors of feeding, thereby acting as so far unique dual regulator of food intake located in a logistically important place where the gastrointestinal tract has initial contact with food.
Authors:
Andreas Stengel; Yvette Taché
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Current gastroenterology reports     Volume:  14     ISSN:  1534-312X     ISO Abbreviation:  Curr Gastroenterol Rep     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-10-26     Completed Date:  2013-04-15     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  100888896     Medline TA:  Curr Gastroenterol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  480-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism,  physiology*
Calcium-Binding Proteins / physiology
DNA-Binding Proteins / physiology
Eating / physiology*
Ghrelin / physiology
Humans
Hunger / physiology*
Nerve Tissue Proteins / physiology
Parietal Cells, Gastric / metabolism*
Peptide Hormones / physiology*
Satiety Response / physiology*
Stomach / metabolism*,  physiology
Grant Support
ID/Acronym/Agency:
DK-41301/DK/NIDDK NIH HHS; P30 DK041301/DK/NIDDK NIH HHS; R01 DK033061/DK/NIDDK NIH HHS; R01 NIH DK 33061/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/DNA-Binding Proteins; 0/Ghrelin; 0/Nerve Tissue Proteins; 0/Peptide Hormones; 0/nucleobindin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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