Document Detail

Gastric Motor Activity in Gastric Pull-Up Esophagectomized Patients With and Without Reflux Symptoms.
MedLine Citation:
PMID:  22884594     Owner:  NLM     Status:  Publisher    
BACKGROUND: Patients frequently experience reflux symptoms of heartburn and regurgitation after a gastric pull-up esophagectomy. The pathogenesis of reflux symptoms is not fully understood. The gastrointestinal tract exhibits a temporally coordinated cyclic motor pattern, termed interdigestive migrating motor contraction, during the interdigestive state. Phase III of interdigestive migrating motor contraction is important in cleaning indigestible solids and basal secretions. Impairment of phase III may result in reflux symptoms of heartburn and regurgitation. The present study evaluated whether gastropyloroduodenal motility after gastric pull-up esophagectomy influences the pathogenesis of reflux symptoms. METHODS: Gastropyloroduodenal motility was recorded by manometry in 20 patients after a gastric pull-up esophagectomy. Esophagectomized patients were questioned about the presence of heartburn or regurgitation, or both. RESULTS: Of 20 patients, 8 (40%) were considered the symptomatic group. Phase III, in which contractions originating from the antrum migrate to the pylorus and then move to the duodenum, was observed in only 1 of 8 patients. In the asymptomatic group, phase III was observed in 8 of 12 patients. A significant correlation was found between the presence of reflux symptoms and the paucity of phase III activity (p = 0.02). CONCLUSIONS: The presence of reflux symptoms after gastric pull-up esophagectomy is significantly associated with the paucity of gastric phase III. Gastric motor activity is important in the occurrence of reflux symptoms.
Toshihiro Nakabayashi; Erito Mochiki; Yoichi Kamiyama; Hiroyuki Kuwano
Related Documents :
17890874 - Cardiac biomarkers in haemodialysis patients: the prognostic value of amino-terminal pr...
18377474 - Long-term functional outcome of patients following the mustard procedure: the next deca...
18977964 - Survey of pediatricians' opinions on donation after cardiac death: are the donors dead?
15139654 - Impedance cardiographic monitoring during pericardiocentesis: comparison with echocardi...
7672164 - Reversible alopecia after single-dose methotrexate treatment in a patient with ectopic ...
20306654 - Role of il-13 in the pathogenesis of bronchial asthma.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-9
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  -     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
Department of Surgery, Gunma Prefectural Cardiovascular Center, Maebashi, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of sex and race on outcome in patients undergoing congenital heart surgery: an analysis of th...
Next Document:  Comparing Aortic Root Replacements: Porcine Bioroots Versus Pericardial Versus Mechanical Composite ...