| Gastric infection by Helicobacter pylori. | |
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MedLine Citation:
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PMID: 19903421 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Helicobacter pylori infection causes chronic active gastritis, ulcer disease, and gastric cancer. Current eradication regimens use a proton pump inhibitor (PPI) and two antibiotics. Triple therapy now has a success rate less than 80%, below the cutoff for efficacious eradication. Antibiotic resistance, inconsistent acid control by PPIs, and poor patient compliance contribute to the failure rate. H. pylori is a neutralophile that has developed special acid acclimation mechanisms to colonize its acidic gastric niche. Identifying the components of these mechanisms will provide novel bactericidal drug targets. Alternatively, better 24-hour acid control would increase the efficacy of antibiotics, leading to dual therapy with improved PPIs and amoxicillin. Studies of acid acclimation by H. pylori have identified several potential eradication targets including UreI, alpha-carbonic anhydrase, and a two-component system. Continuing improvement of PPIs has led to the development of at least three candidate drugs with improved 24-hour acid control. |
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Authors:
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George Sachs; Yi Wen; David R Scott |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current gastroenterology reports Volume: 11 ISSN: 1534-312X ISO Abbreviation: Curr Gastroenterol Rep Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-11 Completed Date: 2010-02-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888896 Medline TA: Curr Gastroenterol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 455-61 Citation Subset: IM |
Affiliation:
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Departments of Physiology and Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA. gsachs@ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Helicobacter Infections
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drug therapy,
microbiology,
physiopathology* Helicobacter pylori* / pathogenicity Humans Stomach Diseases / drug therapy, microbiology*, physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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