Document Detail

Gastric infection by Helicobacter pylori.
MedLine Citation:
PMID:  19903421     Owner:  NLM     Status:  MEDLINE    
Helicobacter pylori infection causes chronic active gastritis, ulcer disease, and gastric cancer. Current eradication regimens use a proton pump inhibitor (PPI) and two antibiotics. Triple therapy now has a success rate less than 80%, below the cutoff for efficacious eradication. Antibiotic resistance, inconsistent acid control by PPIs, and poor patient compliance contribute to the failure rate. H. pylori is a neutralophile that has developed special acid acclimation mechanisms to colonize its acidic gastric niche. Identifying the components of these mechanisms will provide novel bactericidal drug targets. Alternatively, better 24-hour acid control would increase the efficacy of antibiotics, leading to dual therapy with improved PPIs and amoxicillin. Studies of acid acclimation by H. pylori have identified several potential eradication targets including UreI, alpha-carbonic anhydrase, and a two-component system. Continuing improvement of PPIs has led to the development of at least three candidate drugs with improved 24-hour acid control.
George Sachs; Yi Wen; David R Scott
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current gastroenterology reports     Volume:  11     ISSN:  1534-312X     ISO Abbreviation:  Curr Gastroenterol Rep     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-11     Completed Date:  2010-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888896     Medline TA:  Curr Gastroenterol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  455-61     Citation Subset:  IM    
Departments of Physiology and Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA.
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MeSH Terms
Helicobacter Infections / drug therapy,  microbiology,  physiopathology*
Helicobacter pylori* / pathogenicity
Stomach Diseases / drug therapy,  microbiology*,  physiopathology*

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