| Gastric Emptying in Patients With Autoimmune Pancreatitis. | |
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MedLine Citation:
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PMID: 21705948 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES:: Autoimmune pancreatitis (AIP) and its extrapancreatic lesions seem to be clinical manifestations of organs involved in IgG4-related systemic disease. To clarify whether the stomach is a target organ, gastric function was evaluated in patients with AIP. METHODS:: In 6 patients with AIP, gastric emptying was assessed by Carbon 13 (C) acetate breath test before and after steroid therapy. Based on 4-hour breath samples, the half CO2 excretion time (T1/2) and the time of maximal excretion (Tmax) were calculated as gastric emptying parameters. Data of 20 healthy volunteers were used as controls. The number of IgG4-positive plasma cells in gastrofiberscopic biopsy specimens was counted before and after steroid therapy. RESULTS:: Both T1/2 and Tmax in patients with AIP decreased significantly after steroid therapy (T1/2: 1.89 ± 0.21 hours vs 1.69 ± 0.15 hours, P = 0.046; and Tmax: 1.1 ± 0.2 hours vs 0.96 ± 0.2 hours, P = 0.027), and became similar to those of the controls (T1/2: 1.69 ± 0.32 hours and Tmax: 0.98 ± 0.2 hour). The number of IgG4-positive plasma cells infiltrating the gastric mucosa decreased after steroid therapy. CONCLUSIONS:: Gastric emptying was impaired in patients with AIP and improved to the reference range after steroid therapy. The stomach may be a target organ of IgG4-related systemic disease. |
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Authors:
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Hajime Anjiki; Terumi Kamisawa; Taku Tabata; Kensuke Takuma; Naoto Egawa; Takatsugu Yamamoto; Yasushi Kuyama; Yoshihisa Urita; Yusuke Tando; Teruo Nakamura |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-23 |
Journal Detail:
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Title: Pancreas Volume: - ISSN: 1536-4828 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital; †Department of Internal Medicine, Teikyo University School of Medicine; ‡Department of General Medicine and Emergency Care, Toho University School of Medicine, Omori Hospital, Tokyo; §Third Department of Internal Medicine; and ∥Department of Health Science, Hirosaki University School of Medicine, Aomori, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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