Document Detail


Gastric Cytoprotection Beyond Prostaglandins: Cellular and Molecular Mechanisms of Gastroprotective and Ulcer Healing Actions of Antacids.
MedLine Citation:
PMID:  22950493     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This article updates current views on gastric mucosal defense, injury, protection and ulcer healing with a focus on mucosal protective and ulcer healing actions of antacids.  The gastric mucosa is continuously exposed to a variety of noxious factors, both endogenous such as: 0.1N hydrochloric acid, pepsin, bile acids, lysolecithin, H. pylori toxins and exogenous such as NSAIDs, ethanol and others.  Gastric mucosal integrity is maintained by pre-epithelial, epithelial and post-epithelial defense mechanisms permitting the mucosa to withstand exposure to the above damaging factors.  When mucosal defense is weakened or overwhelmed by injurious factors, injury develops in the form of erosions or ulcers.  In the late 1970s Andre Robert and coworkers discovered that microgram amounts of a prostaglandin E2 analog protects the gastric mucosa against a variety of ulcerogenic and necrotizing agents ─ even such strong inducers of injury as 100% ethanol and boiling water. They proposed a new concept of cytoprotection.  Subsequently, other compounds, such as sulfhydryls, sucralfate and epidermal growth factor were shown to exert protective action on gastric mucosa.  Additionally, some antacids have been shown to exert a potent mucosal protective action against a variety of injurious factors and accelerate healing of erosions and gastric ulcers.  These actions of antacids, especially hydrotalcite ─ the newest and the most extensively studied antacid ─ are due to activation of prostaglandin synthesis; binding to and inactivation of pepsin,  bile acids and H. pylori toxins; induction of heat shock proteins; and, activation of genes encoding  growth factors and their receptors.
Authors:
Andrzej Tarnawski; Amrita Ahluwalia; Michael K Jones
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-23
Journal Detail:
Title:  Current pharmaceutical design     Volume:  -     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of California, Irvine, Chief, Gastroenterology, VA Long Beach Healthcare System 5901 E. 7th Street, Long Beach, CA 90822-5201, USA. atarnawski@yahoo.com.
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