| Gastric Bypass vs Sleeve Gastrectomy for Type 2 Diabetes Mellitus: A Randomized Controlled Trial. | |
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MedLine Citation:
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PMID: 21339423 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVES: To determine the efficacies of 2 weight-reducing operations on diabetic control and the role of duodenum exclusion. DESIGN: Double-blind randomized controlled trial. SETTING: Department of Surgery of the Min-Sheng General Hospital, National Taiwan University. PATIENTS: We studied 60 moderately obese patients (body mass index >25 and <35) aged >30 to <60 years who had poorly controlled type 2 diabetes mellitus (T2DM) (hemoglobin A(1c) [HbA(1c)] >7.5%) after conventional treatment (>6 months) from September 1, 2007, through June 30, 2008. Patients and observers were masked during the follow-up, which ended in 2009, 1 year after final enrollment. INTERVENTIONS: Gastric bypass with duodenum exclusion (n = 30) vs sleeve gastrectomy without duodenum exclusion (n = 30). MAIN OUTCOME MEASURES: The primary outcome was remission of T2DM (fasting glucose <126 mg/dL and HbA(1c) <6.5% without glycemic therapy). Secondary measures included weight and metabolic syndrome. Analysis was by intention to treat. RESULTS: Of the 60 patients enrolled, all completed the 12-month follow-up. Remission of T2DM was achieved by 28 (93%) in the gastric bypass group and 14 (47%) in the sleeve gastrectomy group (P = .02). Participants assigned to gastric bypass had lost more weight, achieved a lower waist circumference, and had lower glucose, HbA(1c), and blood lipid levels than the sleeve gastrectomy group. No serious complications occurred in either group. CONCLUSIONS: Participants randomized to gastric bypass were more likely to achieve remission of T2DM. Duodenum exclusion plays a role in T2DM treatment and should be assessed. Trial Registration clinicaltrials.gov Identifier: NCT00540462 (http://www.clinicaltrials.gov). |
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Authors:
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Wei-Jei Lee; Keong Chong; Kong-Han Ser; Yi-Chih Lee; Shu-Chun Chen; Jung-Chien Chen; Ming-Han Tsai; Lee-Ming Chuang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of surgery (Chicago, Ill. : 1960) Volume: 146 ISSN: 1538-3644 ISO Abbreviation: Arch Surg Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9716528 Medline TA: Arch Surg Country: United States |
Other Details:
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Languages: eng Pagination: 143-8 Citation Subset: AIM; IM |
Affiliation:
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Diabetic Center, Min-Sheng General Hospital, National Taiwan University, 168 Jingguo Rd, Taoyuan City, Taoyuan County 330, Taiwan, Republic of China. wjlee_obessurg_tw@yahoo.com.tw. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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