Document Detail


Gastric antral vascular ectasia in systemic sclerosis: demographics and disease predictors.
MedLine Citation:
PMID:  20080908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate patients with systemic sclerosis (SSc) who have gastric antral vascular ectasia (GAVE), to further characterize this disease association, and to identify factors that may predict which patients with SSc are at greatest risk for the development of GAVE. METHODS: Patients with a diagnosis of both SSc and GAVE were identified from the Division of Rheumatology at Georgetown University and Thomas Jefferson University. A chart review was conducted to obtain the demographic data. RESULTS: Twenty-eight patients were included in this analysis, including 17 with diffuse cutaneous (dcSSc) and 11 with limited cutaneous SSc (lcSSc). The mean disease duration at diagnosis with GAVE was 21.5 months for dcSSc and 84.3 months for lcSSc (p = 0.025). Seventy-six percent of patients with dcSSc developed GAVE within 18 months of first scleroderma symptom onset. Over half of patients with early GAVE also had rapidly progressive cutaneous disease. Only 4% had antitopoisomerase I antibody. Although only 1 patient was tested and had positive RNA polymerase (RNAP) III, RNAP III may be overrepresented in this GAVE population. Mean hematocrit levels were 23.8% in dcSSc and 29% in lcSSc. CONCLUSION: dcSSc is associated with earlier development of GAVE, as well as more severe anemia requiring more therapeutic interventions. Rapid progression of cutaneous disease may suggest earlier development of GAVE. Absence of antitopoisomerase I antibodies and presence of antibodies to RNAP III/speckled antinuclear antibody pattern may be useful to identify the subset of patients with SSc with increased risk for GAVE.
Authors:
Kristin M Ingraham; Marie S O'Brien; Max Shenin; Chris T Derk; Virginia D Steen
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Publication Detail:
Type:  Journal Article     Date:  2010-01-15
Journal Detail:
Title:  The Journal of rheumatology     Volume:  37     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-03     Completed Date:  2010-05-20     Revised Date:  2010-07-06    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  603-7     Citation Subset:  IM    
Affiliation:
Division of Rheumatology, Georgetown University, Washington, DC, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antibodies / blood
DNA Topoisomerases, Type I / immunology
European Continental Ancestry Group / ethnology
Female
Gastric Antral Vascular Ectasia / epidemiology*
Hematocrit
Hispanic Americans / ethnology
Humans
Male
Middle Aged
Predictive Value of Tests
RNA Polymerase III / immunology
Risk Factors
Scleroderma, Systemic / complications*,  ethnology*,  immunology
Time Factors
Chemical
Reg. No./Substance:
0/Antibodies; EC 2.7.7.-/RNA Polymerase III; EC 5.99.1.2/DNA Topoisomerases, Type I
Comments/Corrections
Comment In:
J Rheumatol. 2010 Jul;37(7):1544   [PMID:  20595295 ]

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