| Gastric acid hypersecretory states: recent insights and advances. | |
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MedLine Citation:
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PMID: 19903418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastric acid hypersecretory states are characterized by basal hypersecretion of gastric acid and historically include disorders associated with hypergastrinemia, hyperhistaminemia, and those of unknown etiology. Although gastric acid secretion is infrequently measured, it is important to recognize the role of gastric hypersecretion in the symptoms of these disorders because they share several features of pathogenesis and treatment. In this article, recent important articles reporting insights into their diagnosis, pathogenesis, and treatment are reviewed. Particular attention is paid to Zollinger-Ellison syndrome, because it has the most extreme acid hypersecretion of this group of disorders and because numerous recent articles deal with various aspects of the diagnosis, molecular pathogenesis, and treatment of the gastrinoma itself or the acid hypersecretion. Two new hypersecretory disorders are reviewed: rebound acid hypersecretion after the use of proton pump inhibitors and acid hypersecretion with cysteamine treatment in children with cystinosis. |
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Authors:
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Nauramy Osefo; Tetsuhide Ito; Robert T Jensen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review |
Journal Detail:
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Title: Current gastroenterology reports Volume: 11 ISSN: 1534-312X ISO Abbreviation: Curr Gastroenterol Rep Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-11 Completed Date: 2010-02-12 Revised Date: 2011-03-03 |
Medline Journal Info:
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Nlm Unique ID: 100888896 Medline TA: Curr Gastroenterol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 433-41 Citation Subset: IM |
Affiliation:
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Digestive Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9C-103, Bethesda, MD 20892, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cystamine
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adverse effects,
therapeutic use Cystinosis / drug therapy Enzyme Inhibitors / adverse effects, therapeutic use Gastric Acid / secretion* Gastrins / metabolism Histamine / metabolism Humans Proton Pump Inhibitors / adverse effects Stomach Diseases / chemically induced*, diagnosis, physiopathology*, therapy Zollinger-Ellison Syndrome / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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Z01 DK053200-16/DK/NIDDK NIH HHS; Z01 DK053200-17/DK/NIDDK NIH HHS; Z01 DK053215-01/DK/NIDDK NIH HHS; Z01 DK053215-02/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Gastrins; 0/Proton Pump Inhibitors; 51-45-6/Histamine; 51-85-4/Cystamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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