| Gastric acid suppression and outcomes in Clostridium difficile infection: a population-based study. | |
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MedLine Citation:
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PMID: 22766083 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the association of gastric acid suppression medications, including proton pump inhibitors and histamine type 2 blockers, with outcomes in patients with Clostridium difficile infection (CDI) in a population-based cohort. PATIENTS AND METHODS: To understand the association between acid suppression and outcomes in patients with CDI, we conducted a population-based study in Olmsted County, Minnesota, from January 1, 1991, through December 31, 2005. We compared demographic data and outcomes, including severe, severe-complicated, and recurrent CDI and treatment failure, in a cohort of patients with CDI who were treated with acid suppression medications with these outcomes in a cohort with CDI that was not exposed to acid-suppressing agents. RESULTS: Of 385 patients with CDI, 36.4% were undergoing acid suppression (23.4% with proton pump inhibitors, 13.5% with histamine type 2 blockers, and 0.5% with both). On univariate analysis, patients taking acid suppression medications were significantly older (69 vs 56 years; P<.001) and more likely to have severe (34.2% vs 23.6%; P=.03) or severe-complicated (4.4% vs 2.6% CDI; P=.006) infection than patients not undergoing acid suppression. On multivariable analyses, after adjustment for age and comorbid conditions, acid suppression medication use was not associated with severe or severe-complicated CDI. In addition, no association between acid suppression and treatment failure or CDI recurrence was found. CONCLUSION: In this population-based study, after adjustment for age and comorbid conditions, patients with CDI who underwent acid suppression were not more likely to experience severe or severe-complicated CDI, treatment failure, or recurrent infection. |
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Authors:
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Sahil Khanna; Scott L Aronson; Patricia P Kammer; Larry M Baddour; Darrell S Pardi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mayo Clinic proceedings. Mayo Clinic Volume: 87 ISSN: 1942-5546 ISO Abbreviation: Mayo Clin. Proc. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-07-06 Completed Date: 2012-09-14 Revised Date: 2013-02-21 |
Medline Journal Info:
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Nlm Unique ID: 0405543 Medline TA: Mayo Clin Proc Country: England |
Other Details:
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Languages: eng Pagination: 636-42 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2012 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Clostridium difficile* / isolation & purification Comorbidity Enterocolitis, Pseudomembranous / drug therapy, epidemiology* Female Gastric Acid / metabolism* Histamine H2 Antagonists / administration & dosage, adverse effects* Humans Infant Infant, Newborn Male Middle Aged Minnesota / epidemiology Proton Pump Inhibitors / administration & dosage, adverse effects* Recurrence Retrospective Studies Severity of Illness Index Treatment Failure Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG034676/AG/NIA NIH HHS; R01-AG034676/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Histamine H2 Antagonists; 0/Proton Pump Inhibitors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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