Document Detail

Gas transfer and pulmonary blood flow at rest and during exercise in adults 21 years after preterm birth.
MedLine Citation:
PMID:  19498058     Owner:  NLM     Status:  MEDLINE    
RATIONALE: After preterm birth, limited data exist in adulthood regarding alveolar-capillary growth and exercise capacity. Gas transfer at rest through exercise is a noninvasive measure of alveolar-capillary development.
OBJECTIVES: To determine exercise capacity and gas transfer at rest and during exercise in ex-preterm adults.
METHODS: Ex-preterm subjects (n = 60; median gestation, 31.5 wk) recruited at birth underwent exercise testing at 21 years of age and were contemporaneously compared with 50 healthy control subjects.
MEASUREMENTS AND MAIN RESULTS: Subjects exercised on a cycle ergometer, and measurements of heart rate (HR), FRC, effective pulmonary blood flow (Qpeff), stroke volume (SV), DL(CO), Vo(2), arteriovenous oxygen difference (AVO), transit time (TT), respiratory rate (Rf), Vco(2), Ve, Vt, and respiratory quotient (RQ) were made using a respiratory mass spectrometer. In the index study group and control subjects, the median DL(CO) (mmol/min/kPa/m(2)) at rest was 4.33 (95% confidence interval [CI], 4.18-4.62) and 4.75 (95% CI, 4.50-5.10), respectively (P = 0.01), and the median Qpeff (L/min/m(2)) at rest was 3.26 (95% CI, 3.16-3.49) and 3.59 (95% CI, 3.43-3.81), respectively (P = 0.04). Qpeff and DL(CO) values normalized during exercise but were reduced and lower than controls after a recovery period. No significant differences were found in exercise capacity between the groups.
CONCLUSIONS: The data suggest a long-term effect of premature delivery on resting cardiac output and gas transfer, not due to abnormal cardiac or pulmonary function and with no evidence of exercise limitation.
Indra Narang; Andrew Bush; Mark Rosenthal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-04
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  180     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-07     Completed Date:  2009-08-24     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  339-45     Citation Subset:  AIM; IM    
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MeSH Terms
Birth Weight
Blood Flow Velocity / physiology
Cardiac Output / physiology
Exercise Test*
Follow-Up Studies
Gestational Age
Infant, Newborn
Intermittent Positive-Pressure Ventilation
Lung / blood supply*
Mass Spectrometry
Oxygen / blood
Oxygen Inhalation Therapy
Pulmonary Gas Exchange / physiology*
Reference Values
Respiratory Distress Syndrome, Newborn / physiopathology*
Young Adult
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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