Document Detail


Gas-phase chemistry of multiply charged bioions in analytical mass spectrometry.
MedLine Citation:
PMID:  20636047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ion chemistry has long played an important role in molecular mass spectrometry (MS), as it is central to the use of MS as a structural characterization tool. With the advent of ionization methods capable of producing gaseous ions from large biomolecules, the chemistry of gaseous bioions has become a highly active area of research. Gas-phase biomolecule-ion reactions are usually driven by interactions with neutral molecules, photons, electrons, ions, or surfaces. Ion dissociation or transformation into different ion types can be achieved. The types of reaction products observed depend on the characteristics of the ions, the transformation methods, and the time frame of observation. This review focuses on the gas-phase chemistries of ions derived from the electrospray ionization of peptides, proteins, and oligonucleotides, with particular emphasis on their utility in bioanalysis. Various ion-transformation strategies, which further facilitate structural interrogation by converting ions from one type to another, are also summarized.
Authors:
Teng-Yi Huang; Scott A McLuckey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Annual review of analytical chemistry (Palo Alto, Calif.)     Volume:  3     ISSN:  1936-1335     ISO Abbreviation:  Annu Rev Anal Chem (Palo Alto Calif)     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-28     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  101508602     Medline TA:  Annu Rev Anal Chem (Palo Alto Calif)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  365-85     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Gases / chemistry*
Ions / chemistry*
Mass Spectrometry / methods
Oligonucleotides / chemistry
Peptides / chemistry
Proteins / chemistry
Grant Support
ID/Acronym/Agency:
GM 45372/GM/NIGMS NIH HHS; R01 GM045372/GM/NIGMS NIH HHS; R01 GM045372-17/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Gases; 0/Ions; 0/Oligonucleotides; 0/Peptides; 0/Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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