| Gas exchange responses to constant work-rate exercise in patients with glycogenosis type V and VII. | |
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MedLine Citation:
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PMID: 15070817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During constant work-rate exercise above the lactic acidosis threshold, oxygen consumption fails to plateau by 3 minutes, but continues to rise slowly. This slow component correlates closely with the rise in lactate in normal subjects. We investigated if oxygen consumption during constant work-rate exercise could rise after 3 minutes in the absence of a rise in lactate. We studied five patients with McArdle's disease, one patient with phosphofructokinase deficiency and six normal subjects. Subjects performed two 6-minute duration constant work-rate exercise tests at 40 and 70% of peak oxygen consumption. During low-intensity exercise, oxygen consumption reached steady state by 3 minutes in both groups. Lactate rose slightly in control subjects but not in patients. During high-intensity exercise, oxygen consumption rose from the third to the sixth minute by 144 (21-607) ml/minute (median and range) in control subjects and by 142 (73-306) ml/minute in patients (p = not significant, Mann-Whitney U test). Over the same period, lactate (geometric mean and range) rose from 2.68 (1.10-5.00) to 5.39 (2.70-10.00) mmol/L in control subjects, but did not rise in patients (1.20 [0.64-1.60] to 0.70 [0.57-1.20] mmol/L). We conclude that the slow component of oxygen consumption during heavy exercise is not dependent on lactic acidosis. |
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Authors:
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Hean-Yee Ong; Conor S O'Dochartaigh; Sharon Lovell; Victor H Patterson; Karlman Wasserman; D Paul Nicholls; Marshall S Riley |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2004-04-07 |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 169 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-26 Completed Date: 2004-08-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 1238-44 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Royal Victoria Hospital, Belfast, Northern Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis, Lactic
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metabolism,
physiopathology Adult Case-Control Studies Epinephrine / metabolism Exercise / physiology* Exercise Test Exercise Tolerance / physiology Female Glycogen Storage Disease Type V / metabolism, physiopathology* Glycogen Storage Disease Type VII / metabolism, physiopathology* Heart Rate / physiology Humans Lactic Acid / metabolism Male Norepinephrine / metabolism Oxygen Consumption / physiology Pulmonary Gas Exchange / physiology* Pyruvic Acid / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR00425/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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