Document Detail

Gas exchange responses to constant work-rate exercise in patients with glycogenosis type V and VII.
MedLine Citation:
PMID:  15070817     Owner:  NLM     Status:  MEDLINE    
During constant work-rate exercise above the lactic acidosis threshold, oxygen consumption fails to plateau by 3 minutes, but continues to rise slowly. This slow component correlates closely with the rise in lactate in normal subjects. We investigated if oxygen consumption during constant work-rate exercise could rise after 3 minutes in the absence of a rise in lactate. We studied five patients with McArdle's disease, one patient with phosphofructokinase deficiency and six normal subjects. Subjects performed two 6-minute duration constant work-rate exercise tests at 40 and 70% of peak oxygen consumption. During low-intensity exercise, oxygen consumption reached steady state by 3 minutes in both groups. Lactate rose slightly in control subjects but not in patients. During high-intensity exercise, oxygen consumption rose from the third to the sixth minute by 144 (21-607) ml/minute (median and range) in control subjects and by 142 (73-306) ml/minute in patients (p = not significant, Mann-Whitney U test). Over the same period, lactate (geometric mean and range) rose from 2.68 (1.10-5.00) to 5.39 (2.70-10.00) mmol/L in control subjects, but did not rise in patients (1.20 [0.64-1.60] to 0.70 [0.57-1.20] mmol/L). We conclude that the slow component of oxygen consumption during heavy exercise is not dependent on lactic acidosis.
Hean-Yee Ong; Conor S O'Dochartaigh; Sharon Lovell; Victor H Patterson; Karlman Wasserman; D Paul Nicholls; Marshall S Riley
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2004-04-07
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  169     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-26     Completed Date:  2004-08-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1238-44     Citation Subset:  AIM; IM    
Department of Medicine, Royal Victoria Hospital, Belfast, Northern Ireland.
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MeSH Terms
Acidosis, Lactic / metabolism,  physiopathology
Case-Control Studies
Epinephrine / metabolism
Exercise / physiology*
Exercise Test
Exercise Tolerance / physiology
Glycogen Storage Disease Type V / metabolism,  physiopathology*
Glycogen Storage Disease Type VII / metabolism,  physiopathology*
Heart Rate / physiology
Lactic Acid / metabolism
Norepinephrine / metabolism
Oxygen Consumption / physiology
Pulmonary Gas Exchange / physiology*
Pyruvic Acid / metabolism
Grant Support
Reg. No./Substance:
127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

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