Document Detail

Gas exchange, pulmonary mechanics and haemodynamics in adult respiratory distress syndrome: experimental results in Lewe miniature pigs.
MedLine Citation:
PMID:  493731     Owner:  NLM     Status:  MEDLINE    
Adult respiratory distress syndrome (ARDS) is a common medical emergency in respiratory care complicating a great variety of traumas and diseases. An animal model from Lewe miniature pigs has been developed to study the ARDS under standardized conditions; it is based on aspiration pneumonitis, a disorder often observed in ARDS, injuring the lung alveolar surfactant system. The experimental study was conducted under neuroleptanalgesia. ARDS was produced by intratracheal application of hydrochloric acid (0.2 mol/l) in an amount of 1.0 ml/kg body wt. The animals were ventilated automatically by a standardized ventilatory pattern in IPP mode. In all animals the time course of oxygenation ratio (Pa,O2/F1O2), arterial CO2 tension (Pa,CO2), ratio of alveolo--arterial oxygen tension difference to inspired oxygen fraction (Aa,DO2/F1O2), oxygen exchange ratio ((AaDO2/Pa,O2), lung compliance (CL), inspiratory airway resistance (RrsI), dead space ratio VD/VT), pulmonary artery pressure (PAP) and systemic blood pressure were studied. Changes in quasi-static volume--pressure curves, percentage change in lung water content and gross pathological finding were used to integrate the findings into a system of pathophysiological changes in ARDS. The animal group to which hydrochloric acid was administered shows severe pulmonary distress leading to death within 3.5--7.5 h. No significant changes in the measured parameters could be observed in the control group over a 14 h period. The results suggest that aspiration pneumonitis in Lewe miniature pigs is very suitable to investigate various problems in pathogenesis of ARDS. The model provides reproducible results which correlate very well with findings in different ARDS states. The models serves both to compare clinical states and to search for newer therapeutic manoeuvres.
W Kuckelt; R Dauberschmidt; V Bender; U Hieronymi; H Mrochen; K Winsel; P Althaus; M Meyer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Resuscitation     Volume:  7     ISSN:  0300-9572     ISO Abbreviation:  Resuscitation     Publication Date:  1979  
Date Detail:
Created Date:  1979-12-27     Completed Date:  1979-12-27     Revised Date:  2009-08-25    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  13-33     Citation Subset:  IM; S    
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MeSH Terms
Carbon Dioxide / blood
Lung / metabolism*
Lung Compliance
Models, Biological*
Oxygen / blood
Respiratory Distress Syndrome, Adult / metabolism*
Respiratory Function Tests
Swine / metabolism*
Ventilation-Perfusion Ratio*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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