Document Detail

Gas exchange and pulmonary haemodynamic responses to fat emulsions in acute respiratory distress syndrome.
MedLine Citation:
PMID:  9803327     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the gas exchange and pulmonary haemodynamic responses to two different intravenous fat emulsions in patients with acute respiratory distress syndrome (ARDS). DESIGN: Prospective, randomized, double-blind, placebo-controlled study. SETTING: Intensive care unit in a university-affiliated hospital. PATIENTS: 21 patients with ARDS [mean age, 57 +/- 3 (SEM) years; Acute Physiology and Chronic Health Evaluation II, 20 +/- 3; Murray's score, 2.85 +/- 0.12] consecutively admitted. INTERVENTIONS: Patients were assigned to three groups (n = 7 each): group A (LCT) received long-chain triglycerides (20% LCT), group B (MCT/LCT), medium-chain triglycerides/long-chain triglycerides (20% MCT/LCT: 50/50) and group C placebo (0.9% sodium chloride, NaCl). The infusion was always given at the rate of 2 mg/kg min over a total period of 12 h, with a volume infusion of 500 ml in each group. MEASUREMENTS: Data were collected before, immediately after and 12 h after infusion ceased. Pulmonary and systemic haemodynamic and gas exchange variables were measured at each time point. Serum triglyceride cholesterol, and non-esterified fatty acids levels were measured. RESULTS: During LCT infusion, cardiac output, oxygen consumption and oxygen delivery increased (all p < 0.05), whereas pulmonary haemodynamics, arterial oxygen tension, mixed venous partial pressure of oxygen and venous admixture ratio remained essentially unaltered. No changes were observed following MCT/LCT infusion. CONCLUSIONS: The administration of LCT emulsion given at a slow rate did not alter arterial oxygenation because of the beneficial effect of a high cardiac output, hence offsetting the detrimental effect of increased O2 consumption.
J R Masclans; R Iglesia; B Bermejo; M Picó; R Rodriguez-Roisin; M Planas
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Intensive care medicine     Volume:  24     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-01-19     Completed Date:  1999-01-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  918-23     Citation Subset:  IM    
Serveis de Medicina Intensiva, Medicina Preventiva, and Hematologia, Hospital General Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
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MeSH Terms
Blood Gas Analysis
Double-Blind Method
Fat Emulsions, Intravenous / pharmacology*
Hemodynamics / drug effects*
Middle Aged
Prospective Studies
Pulmonary Gas Exchange / drug effects*
Respiratory Distress Syndrome, Adult / blood,  physiopathology*
Severity of Illness Index
Triglycerides / pharmacology*
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Triglycerides

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