| Gas exchange and lung inflammation using nasal intermittent positive-pressure ventilation versus synchronized intermittent mandatory ventilation in piglets with saline lavage-induced lung injury: an observational study. | |
| | |
MedLine Citation:
|
PMID: 18090370 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Physiologic and pathologic comparison of two modes of assisted ventilation, nasal intermittent positive-pressure ventilation (NIPPV) and synchronized intermittent mandatory ventilation (SIMV), in spontaneously breathing term newborn piglets with saline lavage-induced lung injury. DESIGN: After inducing acute lung injury via repetitive saline lavage, piglets were randomized to NIPPV (n = 12) or SIMV (n = 11) and treated for 6 hrs. SETTING: Clinical laboratory. SUBJECTS: Spontaneously breathing term newborn piglets. INTERVENTIONS: Invasive (SIMV) or noninvasive (NIPPV) assisted ventilation for 6 hrs. MEASUREMENTS: Physiologic parameters and arterial blood gases were continuously monitored. At the conclusion of the study, lung tissue was obtained to analyze for evidence of inflammation, including myeloperoxidase, interleukin-8, and hydrogen peroxide levels, as well as for evidence of pathologic injury. MAIN RESULTS: Piglets treated with NIPPV demonstrated higher arterial blood gas pH (p < .001), lower PaCO2 (p < .05), and a lower set respiratory rate (p < .0001) as compared with the SIMV-treated piglets. The piglets in the SIMV group had higher PaO2/PaO2 ratio than those in the NIPPV group (p = .001). There was significantly more interstitial inflammation (p = .04) in the SIMV-treated piglets compared with the NIPPV-treated piglets. Total respiratory rate, heart rate, blood pressure, oxygen saturation, and biochemical markers of lung inflammation were not different between the groups. CONCLUSION: In surfactant-deficient term newborn piglets, NIPPV offers an effective and noninvasive ventilatory strategy with the potential for less pathologic lung inflammation. |
| | |
Authors:
|
Andrea L Lampland; Patricia A Meyers; Cathy T Worwa; Elizabeth C Swanson; Mark C Mammel |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Critical care medicine Volume: 36 ISSN: 1530-0293 ISO Abbreviation: Crit. Care Med. Publication Date: 2008 Jan |
Date Detail:
|
Created Date: 2008-01-03 Completed Date: 2008-02-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
|
Languages: eng Pagination: 183-7 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pediatrics, Division of Neonatology, University of Minnesota Medical School, Minneapolis, MN, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bronchoalveolar Lavage Disease Models, Animal Intermittent Positive-Pressure Ventilation / methods* Pneumonia / metabolism*, physiopathology Pulmonary Gas Exchange* Random Allocation Respiratory Distress Syndrome, Adult / metabolism*, physiopathology, therapy* Sodium Chloride Swine |
| Chemical | |
Reg. No./Substance:
|
7647-14-5/Sodium Chloride |
| Comments/Corrections | |
Comment In:
|
Crit Care Med. 2008 Jan;36(1):349-50
[PMID:
18158453
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Extravascular lung water in sepsis-associated acute respiratory distress syndrome: indexing with pre...
Next Document: Mortality risk and length of stay associated with self-inflicted burn injury: evidence from a nation...