Document Detail


Gas exchange at extreme altitude: results from the British 40th Anniversary Everest Expedition.
MedLine Citation:
PMID:  9230227     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since Messner and Habeler climbed to the summit of Mount Everest (8,848 m) without oxygen in 1978, there has been controversy between scientists trying to explain this feat. Field studies have suggested better respiratory performance than that found during a simulated climb in a hypobaric chamber, but the lack of data at extreme altitude has hampered the debate. We measured arterial oxygen saturation (Sa,O2) and alveolar partial pressure of oxygen (PA,O2) in nine subjects as they climbed from 3,500 to 8,000 m. Four of the climbers reached 8,000 m and one reached the summit. We also tested the effects of breathing supplementary oxygen on Sa,O2 at 6,550 and 8,000 m. At all altitudes tested, we found that both PA,O2 and Sa,O2 were higher than expected from low pressure chamber studies. We also found that standard rates of supplementary oxygen (2 L x min(-1)) were insufficient to restore Sa,O2 above 90% at 8,000 m. The respiratory performance of climbers at extreme altitude is better than expected from sea-level chamber studies, which may, in part, explain why humans can reach the summit (8,848 m) without added oxygen. The better performance is likely to be due to more appropriate acclimatization.
Authors:
A J Peacock; P L Jones
Related Documents :
3382037 - A random survey of anesthesia machines and ancillary monitors in 45 hospitals.
18555377 - Effects of periodic change in pressure and dissolved-oxygen concentration on the incuba...
18236027 - Cardio-renal recovery of hypoxic newborn pigs after 18%, 21% and 100% reoxygenation.
11403067 - Time required for partial pressure of arterial oxygen equilibration during mechanical v...
2452247 - Changes in arterial blood pressure lead to baroreceptor-mediated changes in norepinephr...
8216177 - Time-course of left atrial performance during coronary artery occlusion followed by rep...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  10     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-10     Completed Date:  1997-09-10     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1439-44     Citation Subset:  IM; S    
Affiliation:
Dept of Respiratory Medicine, Western Infirmary, Glasgow, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acclimatization / physiology
Adult
Altitude*
Expeditions*
Female
Great Britain
Humans
Male
Middle Aged
Mountaineering*
Nepal
Oximetry
Oxygen Inhalation Therapy
Pulmonary Gas Exchange / physiology*
Reproducibility of Results
Spirometry
Tibet
Comments/Corrections
Comment In:
Eur Respir J. 1997 Jul;10(7):1431-2   [PMID:  9230224 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  CaN19 expression in benign and malignant hyperplasias of the skin and oral mucosa: evidence for a ro...
Next Document:  Detection of adenovirus E1A DNA in pulmonary fibrosis using nested polymerase chain reaction.