Document Detail

Gas exchange alterations in patients with chronic obstructive lung disease.
MedLine Citation:
PMID:  3979134     Owner:  NLM     Status:  MEDLINE    
In a series of 23 patients with COPD, Wagner et al showed three distinct patterns of VA/Q distributions and a correlation between Burrows' clinical classification and the observed distribution patterns. Using the inert gas method, we studied 51 patients suffering from severe but stable COPD (FEV1 = 0.84 +/- 0.38 L; PaO2 = 58.5 +/- 10.5 mm Hg; PaCo2 = 48 +/- 6 mmHg; Ppa = 22 +/- 8 mmHg) breathing room air in a steady state. The H pattern (high mode of VA in high VA/Q) was found in 24 cases. There was an L pattern (Q mode in low VA/Q units) in nine cases and an HL (high-low) pattern in 16 cases (two patients were assigned another group). The analysis of the distribution data confirmed that VA/Q heterogeneity was the main factor underlying gas exchange disturbances in COPD. The PaO2 of the H subjects was higher than that of both HL (p less than 0.02) and L subjects. The true shunt value in the L group was significantly lower than in the H and HL groups. However, the relationship between clinical or functional aspects and distribution was not direct. The fraction of patients of H, HL, or (H + HL) types was nearly identical in the three clinical groups. The H pattern was found to be predominant in cases of COPD.
R Marthan; Y Castaing; G Manier; H Guenard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  87     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-05-07     Completed Date:  1985-05-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  470-5     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Forced Expiratory Volume
Lung Diseases, Obstructive / blood,  physiopathology*
Middle Aged
Oxygen / blood
Pulmonary Artery / physiopathology
Pulmonary Gas Exchange*
Pulmonary Wedge Pressure
Respiratory Dead Space
Vascular Resistance
Ventilation-Perfusion Ratio
Vital Capacity
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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