Document Detail

Gas distribution in a two-compartment model during volume or pressure ventilation: role of elastic elements.
MedLine Citation:
PMID:  20338267     Owner:  NLM     Status:  MEDLINE    
The results of the studies on pulmonary gas distribution during constant-flow controlled-volume inflation (VCV) and inspiratory constant pressure inflation (PCV) in experimental studies are conflicting. In a mathematical model, with the characteristics of two lung compartments including tissue viscoelastic properties, pulmonary gas distribution was tested by simulating PCV and VCV at same inflation volumes. The compartmental distributions of the tidal volume were compared during CMV and PCV in different configurations obtained by changing the elastic and viscoelastic properties in each compartment, but maintaining the same total values of respiratory mechanics measured in patients. In all instances PCV resulted in a slightly higher air-trapping than in VCV mode. Heterogeneous elastic properties diverted most of the tidal volume towards the less compromised compartment. However, both ventilatory modes provided similar compartmental gas distribution, but during VCV compartmental peak pressures were higher in the sicker compartment respect to PCV. The use of PCV could grant a less remarkable pressure variability able to reduce the potential ventilator-associated lung injury. Moreover, the parameters measured during an end-inspiratory pause could not pinpoint unique characteristics for each configuration.
Vittorio Antonaglia; Umberto Lucangelo; Giuseppe Ristagno; Simona Tantillo; Massimo Ferluga; Lorenzo Torelli; Walter A Zin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-23
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  171     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  225-31     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Department of Anesthesia and Intensive Care, Laboratory of Respiratory Biomechanics, University of Trieste, Cattinara Hospital, Strada di Fiume 447, I-34139 Trieste, Italy.
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MeSH Terms
Elasticity / physiology*
Models, Biological*
Models, Theoretical*
Pulmonary Ventilation / physiology*
Respiratory Mechanics / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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