| Gas diffusion and alveolar-capillary unit in chronic heart failure. | |
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MedLine Citation:
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PMID: 17028107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Alveolar gas diffusion (DLCO) is impaired in chronic heart failure (CHF). Diffusion depends on membrane diffusion (DM) and the amount of blood participating in gas exchange (VC). How DM, VC, and the alveolar-capillary unit behave in relationship to CHF severity is unknown. METHODS AND RESULTS: We measured pulmonary function, including DLCO, DM, VC, and alveolar volume (VA), in 191 CHF patients in NYHA class I-III. CHF patients were grouped accordingly to peak exercise oxygen uptake (pVO(2)): group <12 mL/min/kg (n=24), group 12-16 (n=76), group 16-20 (n=64), and group >20 (n=27). DLCO, DM, VC, and VA were lowest in severe CHF and were linearly related to pVO(2) (DLCO, r=0.577, P<0.001; DM, r=0.490, P<0.001; VC, r=0.216, P<0.01; VA, r=0.565, P<0.01). DM/VC ratio, an index of the alveolar-capillary unit efficiency, was higher in group <12 (0.49+/-0.39 mL/min/mmHg/mL) and >20 (0.46+/-0.29), compared with 12-16 (0.34+/-0.19) and 16-20 (0.35+/-0.17). CONCLUSION: DLCO progressively worsens as CHF severity increases due to reduction in lung tissue participating to gas exchange (low VC and VA). In severe CHF, the few working alveolar-capillary units are the most efficient as shown by the high DM/VC. This is useful for maintaining gas exchange efficiency in severe CHF. |
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Authors:
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Piergiuseppe Agostoni; Maurizio Bussotti; Gaia Cattadori; Eliana Margutti; Mauro Contini; Manuela Muratori; Giancarlo Marenzi; Cesare Fiorentini |
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Publication Detail:
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Type: Journal Article Date: 2006-10-06 |
Journal Detail:
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Title: European heart journal Volume: 27 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-18 Completed Date: 2007-02-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 2538-43 Citation Subset: IM |
Affiliation:
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Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Università di Milano, via Parea 4, 20138 Milan, Italy. piergiuseppe.agostoni@ccfm.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Capillaries
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physiology* Chronic Disease Exercise / physiology Exercise Test Female Heart Failure / physiopathology* Humans Male Middle Aged Pulmonary Alveoli / physiology* Pulmonary Diffusing Capacity / physiology* Respiratory Function Tests |
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