Document Detail


Gas chromatographic--mass spectrometric analysis of optically active metabolites and drugs on a novel chiral stationary phase.
MedLine Citation:
PMID:  701418     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chirasil-Val, a novel chiral polysiloxane-type stationary phase is capable of separating the enantiomers of optically active drugs and metabolites of several compound classes; alpha-amino acides, alpha-amino alcohols, glycols, aromatic and aliphatic alpha-hydroxy carboxylic acids and amines. Due to their high thermal stability, columns coated with Chirasil-Val may be coupled to a mass spectrometer. Potential applications of the new stationary phase include analysis of the optical purity of enantiomeric drugs, determination of the configuration of metabolites, and quantitation of optically active drugs and metabolites using the unnatural enantiometer as internal standard. Direct separation of enantimoers on Chirasil-Val is especially useful if only minute amounts of the optically active compounds are availalbe for analysis.
Authors:
H Frank; G J Nicholson; E Bayer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chromatography     Volume:  146     ISSN:  -     ISO Abbreviation:  J. Chromatogr.     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1978-12-29     Completed Date:  1978-12-29     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0427043     Medline TA:  J Chromatogr     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  197-206     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chromatography, Gas
Mass Spectrometry
Methods
Penicillamine / analysis
Pharmaceutical Preparations / analysis*,  metabolism
Siloxanes
Stereoisomerism*
Chemical
Reg. No./Substance:
0/Pharmaceutical Preparations; 0/Siloxanes; GNN1DV99GX/Penicillamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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