Document Detail

Gardner's syndrome.
MedLine Citation:
PMID:  1154213     Owner:  NLM     Status:  MEDLINE    
The clinical manifestations of Gardner's syndrome were studied in 280 patients from 11 families. Forty-five per cent of the patients at risk inherited the syndrome. Forty-one patients had carcinoma of the intestine develop, with only a 27 per cent survival rate for this type cancer. Eight per cent of the patients with the syndrome showed peritoneal fibrosis and fibrous tumors. They also had carcinomas of the ampulla of Vater, liver, bldder and ovary develop as well as osteogenic sarcoma. The patients without the syndrome had carcinomas of the pancreas and breast develop as well as melanoma and leukemia. Twelve of the 16 patients having had a colectomy and ileoproctostomy showed regression of the remaining polyps of the rectum.
A L Watne; S K Core; J M Carrier
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  141     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-11-08     Completed Date:  1975-11-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-6     Citation Subset:  AIM; IM    
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MeSH Terms
Diagnosis, Differential
Infant, Newborn
Intestinal Polyps / diagnosis,  genetics*
Middle Aged
Neoplasms / prevention & control
Neoplasms, Multiple Primary / diagnosis,  genetics*
Odontogenic Tumors / diagnosis,  genetics
Osteoma / diagnosis,  genetics
Skin Neoplasms / diagnosis,  genetics

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