Document Detail

Gardner's syndrome with duodenal adenomas, gastric adenomyoma and thyroid papillary--follicular adenocarcinoma.
MedLine Citation:
PMID:  657934     Owner:  NLM     Status:  MEDLINE    
A case of a woman with Gardner's syndrome, originally manifested by multiple adenomatous polyps of the colon, is presented. She underwent subtotal colectomy at 14 years of age. Over the next 15 years she had a composite odontoma, an impacted supernumerary tooth, two epidermal inclusion cysts, multicentric paillary-follicular adenocarcinoma of the thyroid, two tubulovillous adenomas of the duodenum in which argyrophilic cells were a prominent feature, and an adenomyoma of the gastric antrum. The presence of all of these lesions in one patient expands the spectrum of lesions seen with Gardner's syndrome and supports the concept of a generalized abnormality of growth regulation as the cause of the syndrome.
A A Keshgegian; H T Enterline
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  21     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:    1978 May-Jun
Date Detail:
Created Date:  1978-08-14     Completed Date:  1978-08-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  255-60     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / pathology*
Adenoma / pathology*
Duodenal Neoplasms / pathology*
Intestinal Polyps / genetics,  pathology*
Neoplasms, Multiple Primary / genetics,  pathology*
Odontogenic Tumors / genetics,  pathology
Osteoma / genetics,  pathology
Skin Neoplasms / genetics,  pathology
Thyroid Neoplasms / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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