Document Detail

Gardenia jasminoides inhibits tumor necrosis factor-alpha-induced vascular inflammation in endothelial cells.
MedLine Citation:
PMID:  20104512     Owner:  NLM     Status:  MEDLINE    
Inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha) enhance binding of low-density lipoprotein to endothelium and upregulate the expression of endothelial leukocyte adhesion molecules during atherogenesis. The present study examined the effect of ethanol extract of Gardenia jasminoides (EGJ) on vascular inflammation in primary cultured human umbilical vein endothelial cells (HUVEC). TNF-alpha-induced the expression of vascular cell adhesion molecule-1 (VCAM-1) and endothelial cell-selectin (E-selectin) expression was inhibited in HUVEC pretreated with EGJ. In a functional study, EGJ dose-dependently attenuated adhesion of HL-60 monocytes to endothelial monolayers. A further analysis indicated that EGJ attenuated TNF-alpha-induced nuclear p65 nuclear factor-kappa B (NF-kappaB) translocation, suggesting that EGJ primarily affects the TNF-alpha-induced NF-kappaB signaling pathway. Taken together, we provided here the first evidence showing that EGJ is able to inhibit TNF-alpha-induced NF-kappaB activation, adhesion molecule expression, and monocyte-endothelial interaction, suggesting an anti-inflammatory role of EGJ, which may be useful in preventing vascular diseases, such as atherosclerosis.
Sun Mi Hwang; Yun Jung Lee; Jung Joo Yoon; So Min Lee; Dae Gill Kang; Ho Sub Lee
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  24 Suppl 2     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  S214-9     Citation Subset:  IM    
Professional Graduate School of Oriental Medicine, Wonkwang University, Chonbuk, Republic of Korea.
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MeSH Terms
Cell Adhesion
Cells, Cultured
E-Selectin / metabolism
Endothelial Cells / drug effects*
Gardenia / chemistry*
I-kappa B Proteins / metabolism
Monocytes / cytology
NF-kappa B / metabolism
Plant Extracts / pharmacology*
Tumor Necrosis Factor-alpha / pharmacology*
Umbilical Veins / cytology
Vascular Cell Adhesion Molecule-1 / metabolism
Reg. No./Substance:
0/E-Selectin; 0/I-kappa B Proteins; 0/NF-kappa B; 0/Plant Extracts; 0/Tumor Necrosis Factor-alpha; 0/Vascular Cell Adhesion Molecule-1; 139874-52-5/NF-kappaB inhibitor alpha
Erratum In:
Phytother Res. 2010 Jun;24 Suppl 2:S233-4

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