Document Detail


Gardenia jasminoides Ellis ethanol extract and its constituents reduce the risks of gastritis and reverse gastric lesions in rats.
MedLine Citation:
PMID:  19425231     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study we investigated the effects of Gardenia jasminoides Ellis (GJE) extract and its constituents, such as ursolic acid and genipin, on gastritis in rats and the growth of human gastric cancer cells. The GJE extract, ursolic acid and genipin showed the acid-neutralizing capacities, the antioxidant activities, and the inhibitory effects on the growth of Helicobacter pylori (H. pylori), which are almost equivalent to positive control compounds. In addition, the GJE extract and ursolic acid had cytotoxic activity against AGS and SUN638 gastric cancer cells. The genipin and ursolic acid inhibited significant HCl/ethanol-induced gastric lesions. Taken together, GJE extract and its constituents might have antigastritic activities, associated with the antioxidant activities, acid-neutralizing capacities, and anti-H. pylori action. Also, we could suggest that genipin and ursolic acid may be useful for the treatment and/or protection of gastritis.
Authors:
Je-Hyuk Lee; Dong-Ung Lee; Choon-Sik Jeong
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  47     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-07     Completed Date:  2009-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1127-31     Citation Subset:  IM    
Affiliation:
Plant Resources Research Institute, Duksung Women's University, Seoul 132-714, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Ulcer Agents*
Antineoplastic Agents, Phytogenic / isolation & purification,  pharmacology
Antioxidants / pharmacology
Cell Line, Tumor
Ethanol
Free Radical Scavengers / pharmacology
Gardenia / chemistry*
Gastritis / chemically induced,  prevention & control*
Helicobacter Infections / drug therapy,  microbiology
Helicobacter pylori
Indicators and Reagents
Iridoids / isolation & purification,  pharmacology
Lipid Peroxidation / drug effects
Male
Plant Extracts / therapeutic use
Rats
Rats, Sprague-Dawley
Solvents
Stomach Neoplasms / pathology,  prevention & control
Stomach Ulcer / chemically induced,  prevention & control*
Triterpenes / isolation & purification,  pharmacology
Chemical
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Antineoplastic Agents, Phytogenic; 0/Antioxidants; 0/Free Radical Scavengers; 0/Indicators and Reagents; 0/Iridoids; 0/Plant Extracts; 0/Solvents; 0/Triterpenes; 64-17-5/Ethanol; 6902-77-8/genipin; 77-52-1/ursolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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