Document Detail

GapA+ Mycoplasma gallisepticum ts-11 has improved vaccine characteristics.
MedLine Citation:
PMID:  21310786     Owner:  NLM     Status:  Publisher    
Mycoplasma gallisepticum (MG) is an important poultry pathogen that causes respiratory disease and loss of production worldwide and is currently controlled with live attenuated vaccines. These vaccines have limitations as they vary in their pathogenicity, the protection afforded, and their transmissibility but have been shown to effectively reduce losses associated with challenge in the field. A live attenuated vaccine, ts-11, has been used for the control of M. gallisepticum in several countries. This vaccine is highly dose dependent and the flock antibody response is weak. GapA is the primary cytadherence molecule in M. gallisepticum and the absence of GapA expression has been observed in the vast majority of cells in the vaccine strain, ts-11. In this study the immunogenicity of a GapA+ M. gallisepticum ts-11 vaccine was investigated in specific pathogen free chickens. Birds vaccinated with GapA+ M. gallisepticum ts-11 were protected against clinical signs of disease following challenge with virulent M. gallisepticum and GapA+ M. gallisepticum ts-11 was shown to be non-pathogenic and more immunogenic at a lower dose than the currently available M. gallisepticum ts-11 vaccine. Thus GapA+ M. gallisepticum ts-11 appears to have improved potential as a vaccine candidate.
Pollob Kumar Shil; Anna Kanci; Glenn Browning; Marc Serge Marenda; Amir Hadji Noormohammadi; Philip Francis Markham
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-10
Journal Detail:
Title:  Microbiology (Reading, England)     Volume:  -     ISSN:  1465-2080     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430468     Medline TA:  Microbiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
The University of Melbourne.
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