| Gap-junctional coupling of mammalian rod photoreceptors and its effect on visual detection. | |
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MedLine Citation:
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PMID: 22399777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The presence of gap junctions between rods in mammalian retina suggests a role for rod-rod coupling in human vision. Rod coupling is known to reduce response variability, but because junctional conductances are not known, the downstream effects on visual performance are uncertain. Here we assessed rod coupling in guinea pig retina by measuring: (1) the variability in responses to dim flashes, (2) Neurobiotin tracer coupling, and (3) junctional conductances. Results were consolidated into an electrical network model and a model of human psychophysical detection. Guinea pig rods form tracer pools of 1 to ∼20 rods, with junctional conductances averaging ∼350 pS. We calculate that coupling will reduce human dark-adapted sensitivity ∼10% by impairing the noise filtering of the synapse between rods and rod bipolar cells. However, coupling also mitigates synaptic saturation and is thus calculated to improve sensitivity when stimuli are spatially restricted or are superimposed over background illumination. |
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Authors:
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Peter H Li; Jan Verweij; James H Long; Julie L Schnapf |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 32 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-08 Completed Date: 2012-04-23 Revised Date: 2012-09-28 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 3552-62 Citation Subset: IM |
Affiliation:
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Departments of Ophthalmology and Physiology, University of California, San Francisco, California 94143, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dark Adaptation / physiology* Female Gap Junctions / metabolism* Guinea Pigs Humans Macaca mulatta Male Models, Neurological Photic Stimulation / methods Retinal Rod Photoreceptor Cells / metabolism* Visual Perception / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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EY02162/EY/NEI NIH HHS; EY07642/EY/NEI NIH HHS; R01 EY007642-18/EY/NEI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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