Document Detail


Gap junction modulation of hippocampal formation theta and local cell discharges in anesthetized rats.
MedLine Citation:
PMID:  21226774     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
During the past decade experimental evidence has accumulated demonstrating that the electrical communication between neurons through gap junctions (GJs) is a necessary neural mechanism underlying oscillations and synchrony. Here we extended our earlier observations concerning the involvement of GJs in hippocampal theta production. Using trimethylamine, a GJ opener, we demonstrated a reversible increase in theta amplitude and power and an increase in the duration of theta epochs. This effect was accompanied by a decrease in the percentage of recorded theta-off cells, an increase in the percentage of recorded theta-on phasic cells, and an increase in the number of rhythmic cell discharges per theta wave. We suggest that all these findings result from an enhanced level of interneuronal excitation, mediated by an increase in the efficacy of local GJ coupling.
Authors:
Renata Bocian; Anna Posluszny; Tomasz Kowalczyk; Paulina Kazmierska; Jan Konopacki
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Publication Detail:
Type:  Journal Article     Date:  2011-01-13
Journal Detail:
Title:  The European journal of neuroscience     Volume:  33     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  471-81     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
Affiliation:
Department of Neurobiology, The University of Łódź, Rewolucji 1905 no. 66, Łódź 90-222, Poland.
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