| Gap junction involvement in secretion: the pancreas experience. | |
| | |
MedLine Citation:
|
PMID: 8977159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. Gap junctions and junction-mediated cell-to-cell communications are obligatory features of gland cells, whatever their secretory product is. 2. Studies on pancreatic islets and acinar cells indicate that cell-to-cell communication via gap junction channels is required for proper biosynthesis, storage and release of both insulin and amylase. 3. However, the endocrine and exocrine portions of the pancreas show opposite connexin (Cx) and coupling changes in relation to the activation and inhibition of their secretory functions. 4. These differences may be accounted for by the expression of Cx43 in pancreatic islets and of Cx26 and Cx32 in pancreatic acini. This alternative expression of connexin isoforms is also found in several other endocrine and exocrine glands. 5. These observations indicate that connexin-made channels play a central role in the control of secretory events. |
| | |
Authors:
|
P Meda |
Related Documents
:
|
15354419 - Cse1/cas overexpression inhibits the tumorigenicity of ht-29 colon cancer cells. 1295729 - Reduced junctional permeability at interrhombomeric boundaries. 2991919 - Potential role of the src gene product in inhibition of gap-junctional communication in... 8242429 - The carcinogen benzo(e)pyrene is metabolized by dm15 cells without an uncoupling effect... 18267319 - Extracellular-loop peptide antibodies reveal a predominant hemichannel organization of ... 8207379 - The pseudoblastema in the wound healing process of the leech hirudo medicinalis l. (hir... 4258549 - Cell adherence reactions in lungworm (protostrongylus) infections of the rocky mountain... 12440199 - Drug sensitivity assay for leukaemic cells by flow cytometry. 19098099 - Two-step oligoclonal development of male germ cells. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Clinical and experimental pharmacology & physiology Volume: 23 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1996 Dec |
Date Detail:
|
Created Date: 1997-03-18 Completed Date: 1997-03-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: AUSTRALIA |
Other Details:
|
Languages: eng Pagination: 1053-7 Citation Subset: IM |
Affiliation:
|
Department of Morphology, University of Geneva Medical School, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Gap Junctions / physiology* Islets of Langerhans / physiology*, secretion* Pancreas / physiology*, secretion* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Where are the gates in gap junction channels?
Next Document: Gap junction and tissue invasion: a comparison of tumorigenesis and pregnancy.