Document Detail


Gap junction- and hemichannel-independent actions of connexins.
MedLine Citation:
PMID:  15955305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Connexins have been known to be the protein building blocks of gap junctions and mediate cell-cell communication. In contrast to the conventional dogma, recent evidence suggests that in addition to forming gap junction channels, connexins possess gap junction-independent functions. One important gap junction-independent function for connexins is to serve as the major functional component for hemichannels, the un-apposed halves of gap junctions. Hemichannels, as independent functional units, play roles that are different from that of gap junctions in the cell. The other functions of connexins appear to be gap junction- and hemichannel-independent. Published studies implicate the latter functions of connexins in cell growth, differentiation, tumorigenicity, injury, and apoptosis, although the mechanistic aspects of these actions remain largely unknown. In this review, gap junction- and hemichannel-independent functions of connexins are summarized, and the molecular mechanisms underlying these connexin functions are speculated and discussed.
Authors:
Jean X Jiang; Sumin Gu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review     Date:  2004-10-22
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1711     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-15     Completed Date:  2005-07-28     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  208-14     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. jiangj@uthscsa.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Bystander Effect / physiology
Cell Differentiation / physiology
Cell Proliferation
Connexins / physiology*
Gap Junctions / physiology*
Neoplasms / etiology
Grant Support
ID/Acronym/Agency:
AR46798/AR/NIAMS NIH HHS; EY12085/EY/NEI NIH HHS; P01 AR046798-06A1/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Connexins
Comments/Corrections

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