| Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells. | |
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MedLine Citation:
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PMID: 16423392 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over many centuries, herbal remedies have treated a variety of ailments. This empiric observational approach has produced a number of leads for formulated medicines. Ganoderma lucidum extract was screened for its anti-proliferative activity using a panel of 26 human cancer cell lines. The six most sensitive hematologic cell lines were: HL-60 (ED50 26 microg/ml), U937 (63 microg/ml), K562 (50 microg/ml), Blin-1 (38 microg/ml), Nalm-6 (30 microg/ml) and RPMI8226 (40 microg/ml). Cell cycle analyses revealed a G2/M arrest, most prominently in HL-60 cells. Four hematopoietic cell lines (HL-60, Blin-1, U937, RPMI8226) were examined for apoptosis, which ranged between 21 and 92%. After exposure to G. lucidum extract, HL-60 cells became multinucleated with an increased DNA content. These results indicate that G. lucidum extract has a profound activity against leukemia, lymphoma and multiple myeloma cells and may be a novel adjunctive therapy for the treatment of hematologic malignancies. |
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Authors:
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Claudia I Müller; Takashi Kumagai; James O'Kelly; Navindra P Seeram; David Heber; H Phillip Koeffler |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-01-19 |
Journal Detail:
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Title: Leukemia research Volume: 30 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-08 Completed Date: 2007-09-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 841-8 Citation Subset: IM |
Affiliation:
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Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States. MullerCI@cshs.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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drug effects* Cell Line, Tumor Cell Proliferation / drug effects Chromatography, High Pressure Liquid / methods Cyclin-Dependent Kinase Inhibitor p21 / drug effects, metabolism Cyclin-Dependent Kinase Inhibitor p27 / drug effects, metabolism Drugs, Chinese Herbal / chemistry, isolation & purification, pharmacology* Humans Leukemia / metabolism*, pathology Lymphoma / metabolism*, pathology Multiple Myeloma / metabolism*, pathology Reishi* / chemistry Sensitivity and Specificity Structure-Activity Relationship Up-Regulation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Cyclin-Dependent Kinase Inhibitor p21; 0/Drugs, Chinese Herbal; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27 |
| Comments/Corrections | |
Comment In:
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Leuk Res. 2006 Jul;30(7):767-8
[PMID:
16458355
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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