Document Detail


Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells.
MedLine Citation:
PMID:  16423392     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over many centuries, herbal remedies have treated a variety of ailments. This empiric observational approach has produced a number of leads for formulated medicines. Ganoderma lucidum extract was screened for its anti-proliferative activity using a panel of 26 human cancer cell lines. The six most sensitive hematologic cell lines were: HL-60 (ED50 26 microg/ml), U937 (63 microg/ml), K562 (50 microg/ml), Blin-1 (38 microg/ml), Nalm-6 (30 microg/ml) and RPMI8226 (40 microg/ml). Cell cycle analyses revealed a G2/M arrest, most prominently in HL-60 cells. Four hematopoietic cell lines (HL-60, Blin-1, U937, RPMI8226) were examined for apoptosis, which ranged between 21 and 92%. After exposure to G. lucidum extract, HL-60 cells became multinucleated with an increased DNA content. These results indicate that G. lucidum extract has a profound activity against leukemia, lymphoma and multiple myeloma cells and may be a novel adjunctive therapy for the treatment of hematologic malignancies.
Authors:
Claudia I Müller; Takashi Kumagai; James O'Kelly; Navindra P Seeram; David Heber; H Phillip Koeffler
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-01-19
Journal Detail:
Title:  Leukemia research     Volume:  30     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-08     Completed Date:  2007-09-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  841-8     Citation Subset:  IM    
Affiliation:
Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States. MullerCI@cshs.org
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MeSH Terms
Descriptor/Qualifier:
Apoptosis / drug effects*
Cell Line, Tumor
Cell Proliferation / drug effects
Chromatography, High Pressure Liquid / methods
Cyclin-Dependent Kinase Inhibitor p21 / drug effects,  metabolism
Cyclin-Dependent Kinase Inhibitor p27 / drug effects,  metabolism
Drugs, Chinese Herbal / chemistry,  isolation & purification,  pharmacology*
Humans
Leukemia / metabolism*,  pathology
Lymphoma / metabolism*,  pathology
Multiple Myeloma / metabolism*,  pathology
Reishi* / chemistry
Sensitivity and Specificity
Structure-Activity Relationship
Up-Regulation / drug effects
Chemical
Reg. No./Substance:
0/Cyclin-Dependent Kinase Inhibitor p21; 0/Drugs, Chinese Herbal; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27
Comments/Corrections
Comment In:
Leuk Res. 2006 Jul;30(7):767-8   [PMID:  16458355 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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