| Ganoderma atrum polysaccharide improves age-related oxidative stress and immune impairment in mice. | |
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MedLine Citation:
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PMID: 22264032 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of the present study was to investigate whether oxidative stress and immune dysfunction could be attenuated by Ganoderma atrum polysaccharide (PSG-1) in D-galactose-induced aging mice, and provide evidence for its effects. The results showed that PSG-1 significantly decreased lipid peroxidation in liver, brain and spleen, but concomitantly increased the activities of superoxide dismutase, catalase and glutathione peroxidase compared with the D-galactose group. Elevation of glutathione contents and attenuation of glutathione disulfide contents were also found in PSG-1 treated animals. Furthermore, the results showed that PSG-1 treatment increased basal lymphocyte proliferation, T cell and B cell proliferation, and enhanced interleukin-2 production. Taken together, our results suggested that PSG-1 had potential as a novel agent to promote health and improve aging associated pathologies, at least in part, via modification of the redox system and improvement of immune function. |
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Authors:
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Wen-Juan Li; Shao-Ping Nie; Xiao-Ping Peng; Xiao-Zhen Liu; Chang Li; Yi Chen; Jing-En Li; Wan-Rui Song; Ming-Yong Xie |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-21 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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