| Gangliosides released by the perfused rat liver are associated to high density lipoprotein. | |
| | |
MedLine Citation:
|
PMID: 1610384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We examine here the delivery of gangliosides from the perfused rat liver into the perfusate. One hour after the administration of [3H]GM1 to recirculating perfused livers, almost 80% of the perfusate radioactive gangliosides were recovered associated to the HDL fraction. This fraction was relatively enriched in radioactive GD1a. The pattern of endogenous gangliosides from perfused livers, rat serum and perfusates were very different: GM3 was the main liver ganglioside, GM1 and GD1a were the most abundant in perfusates being GM3 almost absent; GM3, GM1 and GD1a were present in rat serum in similar proportions. Using a non-recirculating perfusion protocol, radioactive gangliosides were found in the HDL fraction since 15 minutes after the administration of [3H]GM1. These results suggest that rat liver supplies the perfusates with some gangliosides and that they are associated to HDL. These facts arise the possibility that the liver is one of the source of serum gangliosides. |
| | |
Authors:
|
S C Kivatinitz; P Favini; R Ghidoni |
Related Documents
:
|
1951624 - Activated neutrophils injure the isolated, perfused rat liver by an oxygen radical-depe... 6182964 - A simplified timm stain procedure compatible with formaldehyde fixation and routine par... 21113484 - Effect of terahertz electromagnetic irradiation at nitric oxide frequencies on concentr... 8615764 - Rapid reduction and removal of hdl- but not ldl-associated cholesteryl ester hydroperox... 9000674 - Enhancement of proliferation of intrasplenically transplanted hepatocytes in cirrhotic ... 7413604 - A rapid method for the separation of free and membrane-bound polysomes of rat liver by ... |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biochemistry international Volume: 26 ISSN: 0158-5231 ISO Abbreviation: Biochem. Int. Publication Date: 1992 Apr |
Date Detail:
|
Created Date: 1992-07-17 Completed Date: 1992-07-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8100311 Medline TA: Biochem Int Country: AUSTRALIA |
Other Details:
|
Languages: eng Pagination: 821-9 Citation Subset: IM |
Affiliation:
|
Department of Medical Chemistry and Biochemistry, University of Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals G(M1) Ganglioside / metabolism Gangliosides / secretion* Lipoproteins / secretion Lipoproteins, HDL / secretion* Liver / metabolism, secretion* Male Perfusion Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
|
0/Gangliosides; 0/Lipoproteins; 0/Lipoproteins, HDL; 37758-47-7/G(M1) Ganglioside |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Erythrocyte carbonic anhydrase: a major intracellular enzyme to regulate cellular sodium metabolism ...
Next Document: Effects of androgen on phosphorylation of chromosomal proteins in mouse submandibular gland.