| Gangliosides of hepatoma 27, normal and regenerating rat liver. | |
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MedLine Citation:
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PMID: 177287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The highly malignant rat hepatoma 27 was found to have increased amounts of lipid-bound sialic acid as compared with normal liver whereas in regenerating liver the lipid-bound sialic acid level was reduced. In contrast to the liver the hepatoma contained higher amounts of disialogangliosides and no trisialogangliosides, which are abundant in the liver. The main disialoganglioside of the hepatoma had no analogue among the liver gangliosides and was identified as Gal-GalNAc(AcNeu-AcNeu)-Glc-Cer (GD1b), which in other tissues is known to be a precursor of trisialogangliosides. These findings may be explained by a reduced activity of glycosyltransferases in the hepatoma and apparently do not simply reflect differences in growth rate since the ganglioside pattern of regenerating rat liver was not altered significantly in comparison with the liver. Liver and hepatoma microsomes were found to be enriched in gangliosides as compared with whole cells, liver mitochondria were slightly poorer, while the ganglioside level of hepatoma mitochondria was much higher than that of the hepatoma cells. It thus appears that the existing image of the plasma membranes as the only sites of high ganglioside concentration may not hold true for weakly differentiated hepatomas of high malignancy. |
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Authors:
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E V Dyatlovitskaya; A M Novikov; N P Gorkova; L D Bergelson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of biochemistry / FEBS Volume: 63 ISSN: 0014-2956 ISO Abbreviation: Eur. J. Biochem. Publication Date: 1976 Apr |
Date Detail:
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Created Date: 1976-07-06 Completed Date: 1976-07-06 Revised Date: 2007-07-23 |
Medline Journal Info:
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Nlm Unique ID: 0107600 Medline TA: Eur J Biochem Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 357-64 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / metabolism* Galactosamine / analysis Galactose / analysis Gangliosides* / metabolism Glucose / analysis Liver / metabolism* Liver Neoplasms / metabolism* Liver Regeneration* Microsomes / metabolism Microsomes, Liver / metabolism Mitochondria / metabolism Mitochondria, Liver / metabolism Neoplasms, Experimental / metabolism Rats Sialic Acids / analysis Sphingosine / analysis |
| Chemical | |
Reg. No./Substance:
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0/Gangliosides; 0/Sialic Acids; 123-78-4/Sphingosine; 26566-61-0/Galactose; 50-99-7/Glucose; 7535-00-4/Galactosamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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