| Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons. | |
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MedLine Citation:
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PMID: 10481046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Analysis of the binding of cholera toxin to ganglioside GM1 in both living and fixed neurons, and comparison with the distribution of defined axonal and dendritic proteins, demonstrates that ganglioside GM1 is distributed in a non-polarized manner over the axonal and dendritic plasma membranes of mature, cultured hippocampal neurons. Likewise, ganglioside GD1b is also distributed in a non-polarized manner. These results suggest that a recent report [Ledesma, M.D. et al. EMBO J. 18 (1999) 1761-1771] proposing that ganglioside GM1 is highly enriched on the axonal versus dendritic membrane of hippocampal neurons may need to be re-evaluated. |
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Authors:
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H Shogomori; M A Burack; G Banker; A H Futerman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 458 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-13 Completed Date: 1999-10-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 107-11 Citation Subset: IM |
Affiliation:
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Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axons / metabolism Boron Compounds / metabolism Cell Differentiation Cell Polarity* Cells, Cultured Cholera Toxin / metabolism Dendrites / metabolism Fluorescent Dyes / metabolism G(M1) Ganglioside / chemistry, metabolism* Gangliosides / chemistry, metabolism* Hippocampus / cytology, metabolism* Neurons / cytology, metabolism* Rats |
| Chemical | |
Reg. No./Substance:
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0/4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; 0/Boron Compounds; 0/Fluorescent Dyes; 0/Gangliosides; 19553-76-5/ganglioside, GD1b; 37758-47-7/G(M1) Ganglioside; 9012-63-9/Cholera Toxin |
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