| Ganglioside patterns of metastatic and non-metastatic transplantable hepatocellular carcinomas of the rat. | |
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MedLine Citation:
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PMID: 544926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In previous investigations, we correlated levels of sialic acid, gangliosides, and ganglioside glycosyltransferases with tumorigenesis over a 24-week continuum of growth of hepatocellular neoplasms of the rat induced by the carcinogen N-2-fluorenylacetamide. However, metastatic tumors developed only rarely and were not analyzed. To investigate surface changes associated with metastasis, well-differentiated and poorly differentiated hepatocellular carcinomas were transplanted to syngeneic recipient rats. From those, several metastatic and nonmetastatic isolates were obtained and compared. Both total and ganglioside sialic acid amounts in transplantable hepatomas were elevated above control liver values but were significantly lower for metastatic lines than for nonmetastatic lines. The nonmetastatic lines were characterized by ganglioside patterns depleted in the precursor ganglioside GM3 (sialic acid-galactose-glucose-ceramide) and elevated in the products of the monosialoganglioside pathway. In contrast, metastatic isolates exhibited a restoration of GM3 and nearer normal amounts of other gangliosides. The findings point to differences in sialic acid-containing glycolipids, comparing metastatic and nonmetastatic hepatocellular carcinomas, and further extend the concept that ganglioside alterations do not cause tumorigenesis but are the end result of a cascade of events which apparently continue beyond the onset of metastasis. |
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Authors:
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T M Kloppel; D J Morré; L B Jacobsen |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of supramolecular structure Volume: 11 ISSN: 0091-7419 ISO Abbreviation: J. Supramol. Struct. Publication Date: 1979 |
Date Detail:
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Created Date: 1980-07-22 Completed Date: 1980-07-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0330464 Medline TA: J Supramol Struct Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 485-92 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2-Acetylaminofluorene Animals Gangliosides / analysis* Liver Neoplasms / analysis*, chemically induced Liver Regeneration Male Membrane Lipids / analysis* Neoplasm Metastasis Neoplasm Transplantation Neoplasms, Experimental / analysis Rats Rats, Inbred Strains Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Gangliosides; 0/Membrane Lipids; 53-96-3/2-Acetylaminofluorene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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