Document Detail

Ganglioside pattern of normal human brain, from samples obtained at surgery. A study especially referred to alkali labile species.
MedLine Citation:
PMID:  6530404     Owner:  NLM     Status:  MEDLINE    
The ganglioside pattern from normal human temporal cortex and cerebellum has been studied in fresh specimens obtained at surgery. The analyses have been performed by two-dimensional thin layer chromatography with an intermediate ammonia treatment which is a methodology particularly suitable for resolving alkali labile gangliosides. Alkali labile gangliosides were detected in all the analyzed specimens and their content contributed to 23% and 11% of total lipid bound sialic acid, in temporal cortex and cerebellum, respectively.
L Riboni; A Malesci; S M Gaini; S Sonnino; R Ghidoni; G Tettamanti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biochemistry     Volume:  96     ISSN:  0021-924X     ISO Abbreviation:  J. Biochem.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-05-16     Completed Date:  1985-05-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376600     Medline TA:  J Biochem     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1943-6     Citation Subset:  IM    
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MeSH Terms
Brain Chemistry*
Cerebellum / analysis
Chemical Phenomena
Chromatography, Thin Layer
Gangliosides / analysis*,  isolation & purification
Hydrogen-Ion Concentration
Middle Aged
N-Acetylneuraminic Acid
Sialic Acids / analysis
Temporal Lobe / analysis
Reg. No./Substance:
0/Gangliosides; 0/Sialic Acids; 131-48-6/N-Acetylneuraminic Acid

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