| Ganglioside distribution in the liver of inbred strains of rats and the cancerous liver of LEC rats. | |
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MedLine Citation:
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PMID: 8468332 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gangliosides in the livers of various inbred strains of rats and hepatoma of LEC rats were purified and analyzed by thin-layer chromatography. The patterns of ganglioside distribution in these rat livers were classified into three phenotypes depending on the strain, that is, a-type (ACI, LEA, LEW, BUF), b-type (WKAH, SHR/SP), and LEC type, which are characterized by dominance of a- or b-series of gangliosides, or a variation of a-type, respectively. A sex difference was also recognized in the molar ratio of GM3 which was much higher in males (60-75%) than in females (33-56%) except in LEC rats. In addition, the content of a-series gangliosides was lower and the content of b-series gangliosides was higher in a-type male rats than in a-type female rats. The opposite was true in b-type rats. LEC rats were an exception, characterized by no sex difference and a quite low content of b-series gangliosides. The LEC rat is a mutant strain that spontaneously develops fulminant hepatitis around 14 to 20 weeks of age and hepatoma at 1 to 1.5 years old. The gangliosides of the hepatoma were characterized by the appearance of the newly synthesized gangliosides, fucosyl-GM1 and alpha-galactosyl alpha-fucosyl GM1 (BGM1). In particular, BGM1 ganglioside accumulated in the hepatoma of female rats. |
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Authors:
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N Kasai; A Kamimura; I Miyoshi; T Ariga |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biochemistry Volume: 113 ISSN: 0021-924X ISO Abbreviation: J. Biochem. Publication Date: 1993 Feb |
Date Detail:
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Created Date: 1993-05-13 Completed Date: 1993-05-13 Revised Date: 2007-12-19 |
Medline Journal Info:
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Nlm Unique ID: 0376600 Medline TA: J Biochem Country: JAPAN |
Other Details:
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Languages: eng Pagination: 251-7 Citation Subset: IM |
Affiliation:
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Institute for Animal Experimentation, Hokkaido University School of Medicine. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbohydrate Sequence Female Gangliosides / biosynthesis, metabolism* Liver / metabolism* Liver Neoplasms, Experimental / metabolism* Male Molecular Sequence Data Rats Rats, Inbred Strains Rats, Mutant Strains Sex Characteristics Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Gangliosides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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