Document Detail


Ganglionic herpes simplex and systemic acyclovir.
MedLine Citation:
PMID:  6266375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The therapeutic and systemic effects of acyclovir on ganglionic herpes simplex virus (HSV) in mice were studied by varying the duration of treatment and the time of removal of ganglia for co-cultivation after treatment had ended. When treatment was started three hours after infection, it had a significant therapeutic effect even when the ganglionic culture was delayed 17 days after the end of acyclovir therapy. When treatment was started 24 hours after infection, it had no significant effect under the same circumstances. The treatment of established latent ganglionic HSV for 15 days with acyclovir had a significant therapeutic effect compared with control mice when ganglia were cultured two days after treatment had ended, but this effect was lost by ten and 21 days after the end of therapy. This indicates that acyclovir has a transient suppressive effect on part of the viral ganglionic reservoir, but it also indicates that these titers quickly reestablish themselves with the removal of drug therapy.
Authors:
D Pavan-Langston; N H Park; M Hettinger
Related Documents :
16061535 - Historical correlates of genital herpes simplex virus type 2 infection in men attending...
19857385 - New concepts in understanding genital herpes.
20199435 - Recurrent herpes simplex infection in multiple locations in an otherwise healthy boy.
20536295 - Valacyclovir: approved and off-label uses for the treatment of herpes virus infections ...
11398255 - Factors involved in producing a sustained experimental dermatophyte infection (trichoph...
9866745 - Sporadic stec o157 infection: secondary household transmission in wales.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  99     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-09-22     Completed Date:  1981-09-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1417-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acyclovir
Animals
Antiviral Agents / administration & dosage*
Ganglia, Autonomic / microbiology*
Guanine / administration & dosage,  analogs & derivatives*
Herpes Simplex / drug therapy*
Keratitis, Dendritic / prevention & control
Male
Mice
Simplexvirus / drug effects*,  isolation & purification
Time Factors
Grant Support
ID/Acronym/Agency:
DE-05572/DE/NIDCR NIH HHS; ENYS-02268//PHS HHS
Chemical
Reg. No./Substance:
0/Antiviral Agents; 59277-89-3/Acyclovir; 73-40-5/Guanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sarcoidosis of the lacrimal sac.
Next Document:  The current status of the vitamin D metabolites.