Document Detail


Ganglion cells in the posterior cricoarytenoid muscle of the rat following experimental denervation.
MedLine Citation:
PMID:  15513555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate morphological changes of the i.m. ganglion cells in the posterior cricoarytenoid (PCA) muscle of the rat following denervation of the recurrent laryngeal nerve. MATERIAL AND METHODS: The recurrent laryngeal nerve on the left side of the rat was resected. Three weeks after transection, the PCA muscle was removed for morphological study using light and electron microscopy. RESULTS: No morphological changes were found in the i.m. ganglion cells in the PCA muscle, even though the myelinated nerve fibers were destroyed and had disappeared in ramified i.m. bundles. Around the cell body, numerous non-myelinated nerve fibers were found; these contained a large number of clear, spherical synaptic vesicles approximately 50 nm in diameter and several dense-cored vesicles approximately 100 nm in diameter. In contrast, neuromuscular junctions in most muscle fibers with partially disoriented and/or disintegrated myofibrils showed degenerative figures. In some instances, however, multiple nerve terminals were detected in contact with the postsynaptic membrane. Like the varicose swellings of non-myelinated nerve fibers around the ganglion cell body, these nerve terminals contained, in addition to clear synaptic vesicles (50 nm in diameter), several dense-cored vesicles (100 nm in diameter). CONCLUSION: We suggest that i.m. ganglion cells in the rat PCA muscle may supply postganglionic nerve fibers to the denervated neuromuscular junctions after transection of the nerve.
Authors:
Takahiko Yamagata; Seiji Kawakita; Masamitsu Hyodo; Junzo Desaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  124     ISSN:  0001-6489     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-29     Completed Date:  2005-02-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1090-4     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan. yamagata@m.ehime-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Ganglia, Autonomic / cytology,  physiology*
Laryngeal Muscles / innervation*,  pathology
Microscopy, Electron
Muscle Denervation* / methods
Neuromuscular Junction / ultrastructure
Rats
Rats, Wistar
Recurrent Laryngeal Nerve / surgery*

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