Document Detail

Ganglion cells from chick retina display multiple functional nAChR subtypes.
MedLine Citation:
PMID:  15076758     Owner:  NLM     Status:  MEDLINE    
We have examined the properties of nicotinic acetylcholine receptors in embryonic chick retinal ganglion cells. Ganglion cells, identified according to morphological and physiological criteria, displayed spontaneous or induced action potentials. In 94/99 cells acetylcholine pulses evoked responses. In current clamp mode, acetylcholine provoked membrane depolarization and triggered action potentials. Under voltage clamp conditions, acetylcholine evoked inward currents that were readily blocked by d-tubocurarine. Antagonists specific for homomeric (alpha-bungarotoxin) and heteromeric (dihydro-beta-erythroidine) receptors revealed that ganglion cells express multiple functional receptor subtypes. These findings demonstrate that ACh modulates the electrical activity of these cells and is likely to mediate synaptic transmission. The presence of multiple receptor subtypes may contribute to processing and transmission of information in the retina.
M Lecchi; A Marguerat; A Ionescu; M Pelizzone; P Renaud; J Sommerhalder; A B Safran; E Tribollet; D Bertrand
Related Documents :
21911078 - Chlamydia pneumoniae binds to the lectin-like oxidized ldl receptor for infection of en...
21899328 - Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis and p...
21837568 - Fluorescence fluctuation analysis of receptor kinase dimerization.
20798508 - Auto-positive feedback regulation for nicotinic acetylcholine receptors by protein kina...
19109138 - App1: an antiphagocytic protein that binds to complement receptors 3 and 2.
8712778 - The molecular basis of x-linked severe combined immunodeficiency: defective cytokine re...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  15     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-04-12     Completed Date:  2004-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  307-11     Citation Subset:  IM    
Department of Physiology, Faculty of Medicine, CH-1211, CMU 1, rue M. Servet, Geneva 4, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acetylcholine / metabolism*,  pharmacology
Action Potentials / drug effects,  physiology
Bungarotoxins / pharmacology
Cell Differentiation / drug effects,  physiology
Chick Embryo
Dihydro-beta-Erythroidine / pharmacology
Nicotinic Antagonists / pharmacology
Patch-Clamp Techniques
Receptors, Nicotinic / drug effects,  metabolism*
Retina / cytology,  embryology,  metabolism*
Retinal Ganglion Cells / cytology,  drug effects,  metabolism*
Synaptic Transmission / drug effects,  physiology*
Tubocurarine / pharmacology
Reg. No./Substance:
0/Bungarotoxins; 0/Nicotinic Antagonists; 0/Receptors, Nicotinic; 23255-54-1/Dihydro-beta-Erythroidine; 51-84-3/Acetylcholine; 57-95-4/Tubocurarine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Surface segregation influences pre-attentive search in depth.
Next Document:  Preliminary evidence for spectral opponency in the suppression of melatonin by light in humans.