| Ganglion cell death in glaucoma: pathology recapitulates ontogeny. | |
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MedLine Citation:
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PMID: 7546696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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I review some improvements in our knowledge about the death of retinal ganglion cells in glaucoma during the last 20 years. These include the realisation that glaucoma damage precedes its detection by perimetry, the fact that the lamina cribrosa is a major site of axonal injury to ganglion cells, and the association between regional structure of optic nerve head connective tissue and the pattern of glaucoma damage. The selective susceptibility of larger retinal ganglion cells and its functional significance are described. Apoptosis is the mode of cell death in at least some ganglion cells in experimental glaucoma. This supports a theory that retrograde axonal transport failure leads to loss of trophic factor influence on ganglion cells, causing them to initiate their own suicide. As a consequence of this theory, two therapeutic avenues are suggested for prevention of glaucoma injury and cell death: delivery of trophic factors and manipulation of ganglion cell genetic expression of controlling influences over programmed cell death. |
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Authors:
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H A Quigley |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Australian and New Zealand journal of ophthalmology Volume: 23 ISSN: 0814-9763 ISO Abbreviation: Aust N Z J Ophthalmol Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-11-21 Completed Date: 1995-11-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8505423 Medline TA: Aust N Z J Ophthalmol Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 85-91 Citation Subset: IM |
Affiliation:
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Glaucoma Service, Dana Center for Preventive Ophthalmology, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis Axons / pathology, physiology Cell Death Glaucoma / etiology, pathology* Humans Retinal Ganglion Cells / pathology*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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EY 01765/EY/NEI NIH HHS; EY 02120/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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