Document Detail


Ganglion cell death in glaucoma: from mice to men.
MedLine Citation:
PMID:  17973839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glaucoma results from the degeneration of retinal ganglion cells and their axons. Over the last 20 years several important advancements have been made in our understanding of the molecular pathology of this disease, particularly through the development of rat models of experimental glaucoma and the characterization of a spontaneous secondary form of glaucoma in DBA/2 substrains of inbred mice. One of these advances is the observation that ganglion cells die by apoptosis, an intrinsic molecular pathway of programmed cell death. An important aspect of this cell death process is the concept that these cells actually undergo compartmentalized self-destruction. Importantly, genetic evidence now suggests that axons die independently of the apoptotic program that executes the cell body or soma. This review briefly summarizes some of the most significant developments in glaucoma research, with respect to the process of ganglion cell degeneration.
Authors:
Robert W Nickells
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Veterinary ophthalmology     Volume:  10 Suppl 1     ISSN:  1463-5216     ISO Abbreviation:  Vet Ophthalmol     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-11-01     Completed Date:  2008-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887377     Medline TA:  Vet Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  88-94     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology and Visual Sciences, University of Wisconsin, WI 53706, USA. nickells@wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Glaucoma / pathology*
Humans
Mice
Mice, Inbred DBA
Retinal Ganglion Cells / pathology*
Species Specificity
Grant Support
ID/Acronym/Agency:
R01 EY12223/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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