Document Detail

Ganglion cell death in glaucoma: from mice to men.
MedLine Citation:
PMID:  17973839     Owner:  NLM     Status:  MEDLINE    
Glaucoma results from the degeneration of retinal ganglion cells and their axons. Over the last 20 years several important advancements have been made in our understanding of the molecular pathology of this disease, particularly through the development of rat models of experimental glaucoma and the characterization of a spontaneous secondary form of glaucoma in DBA/2 substrains of inbred mice. One of these advances is the observation that ganglion cells die by apoptosis, an intrinsic molecular pathway of programmed cell death. An important aspect of this cell death process is the concept that these cells actually undergo compartmentalized self-destruction. Importantly, genetic evidence now suggests that axons die independently of the apoptotic program that executes the cell body or soma. This review briefly summarizes some of the most significant developments in glaucoma research, with respect to the process of ganglion cell degeneration.
Robert W Nickells
Related Documents :
8825409 - Evolutionary conservation of a genetic pathway of programmed cell death.
10581389 - Parvovirus h-1-induced cell death: influence of intracellular nad consumption on the re...
3056619 - Suicidal death of rat chloroleukaemia cells by activation of the long interspersed repe...
21289309 - Rnai screen of the druggable genome identifies modulators of proteasome inhibitor sensi...
8825579 - Hypothesis: patient with possible disturbance in programmed cell death.
16123779 - Caspase-1 activation of caspase-6 in human apoptotic neurons.
17174019 - Apoptotic related biochemical changes in human amnion cells induced by tributyltin.
21775699 - Automated patch clamp on mesc-derived cardiomyocytes for cardiotoxicity prediction.
23454789 - Degeneration and cell regeneration in the midgut of podisus nigrispinus (heteroptera: p...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Veterinary ophthalmology     Volume:  10 Suppl 1     ISSN:  1463-5216     ISO Abbreviation:  Vet Ophthalmol     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-11-01     Completed Date:  2008-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887377     Medline TA:  Vet Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  88-94     Citation Subset:  IM    
Department of Ophthalmology and Visual Sciences, University of Wisconsin, WI 53706, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Glaucoma / pathology*
Mice, Inbred DBA
Retinal Ganglion Cells / pathology*
Species Specificity
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Measurement of retinal nerve fiber layer thickness in normal and glaucomatous Cocker Spaniels by sca...
Next Document:  Effects of topical 2% dorzolamide hydrochloride alone and in combination with 0.5% timolol maleate o...