Document Detail

Ganglion blockade does not prevent cortisol-induced hypertension in man.
MedLine Citation:
PMID:  15810994     Owner:  NLM     Status:  MEDLINE    
1. The aim of the present study was to assess the effect of ganglion blockade on blood pressure in cortisol treated human subjects. 2. Four healthy male subjects were treated with cortisol 80 mg/day for a 5-day period. Ganglion blockade was achieved by intravenous trimethaphan. 3. Ganglion blockade did not significantly alter blood pressure in the pretreatment phase or on the last day of cortisol treatment. 4. Taken together with our previous observations that sympathetic activity is unaltered or reduced by cortisol, these results suggest that cortisol induced hypertension in humans is not a result of overactivity of the autonomic nervous system.
Paula M Williamson; Sim Hom Tam; John J Kelly; Judith A Whitworth
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  32     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-06     Completed Date:  2005-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  294-6     Citation Subset:  IM    
Department of Medicine, St George Hospital, University of New South Wales, Sydney, Australia.
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MeSH Terms
Autonomic Nervous System / drug effects,  physiology
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Ganglionic Blockers / pharmacology*
Heart Rate / drug effects
Hydrocortisone / pharmacology*
Hypertension / chemically induced,  drug therapy,  prevention & control*
Trimethaphan / pharmacology
Reg. No./Substance:
0/Ganglionic Blockers; 50-23-7/Hydrocortisone; 7187-66-8/Trimethaphan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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