| Ganglion blockade does not prevent cortisol-induced hypertension in man. | |
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MedLine Citation:
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PMID: 15810994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The aim of the present study was to assess the effect of ganglion blockade on blood pressure in cortisol treated human subjects. 2. Four healthy male subjects were treated with cortisol 80 mg/day for a 5-day period. Ganglion blockade was achieved by intravenous trimethaphan. 3. Ganglion blockade did not significantly alter blood pressure in the pretreatment phase or on the last day of cortisol treatment. 4. Taken together with our previous observations that sympathetic activity is unaltered or reduced by cortisol, these results suggest that cortisol induced hypertension in humans is not a result of overactivity of the autonomic nervous system. |
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Authors:
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Paula M Williamson; Sim Hom Tam; John J Kelly; Judith A Whitworth |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 32 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-06 Completed Date: 2005-09-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: Australia |
Other Details:
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Languages: eng Pagination: 294-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, St George Hospital, University of New South Wales, Sydney, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autonomic Nervous System
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drug effects,
physiology Blood Pressure / drug effects Dose-Response Relationship, Drug Ganglionic Blockers / pharmacology* Heart Rate / drug effects Humans Hydrocortisone / pharmacology* Hypertension / chemically induced, drug therapy, prevention & control* Male Trimethaphan / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Ganglionic Blockers; 50-23-7/Hydrocortisone; 7187-66-8/Trimethaphan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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