Document Detail


Ganciclovir treatment for cytomegalovirus infection in immunocompromised patients with renal disease.
MedLine Citation:
PMID:  1667044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The safety and efficacy of a 10-day course of ganciclovir therapy was assessed in 17 consecutive patients with proven cytomegalovirus infection. The patients were receiving immunosuppressive therapy for a variety of non-malignant renal conditions, including renal transplantation (seven patients), small vessel vasculitis (six patients), systemic lupus erythematosus (three patients) and Goodpasture's disease (one patient). Fifteen patients were pyrexial at the time of their cytomegalovirus infection. Twelve patients had pneumonitis manifesting as a pulmonary parenchymal infiltrate or a reduction in gas transfer. Fourteen patients had a significant lymphopenia (lymphocyte count less than 1 x 10(9)/l), nine were leucopenic (white cell count less than 3.5 x 10(9)/l) and nine had abnormal liver biochemistry. One patient had an infection of the ileum and one an infection of the larynx. All these disease manifestations responded completely to a single course of ganciclovir therapy. There were no clinical relapses and no side effects were observed. Ganciclovir is a safe and effective therapy when administered early in the course of cytomegalovirus infection in immunosuppressed patients with renal impairment.
Authors:
C N Ross; H L Beynon; J S Savill; R P Watkins; J Cohen; C D Pusey; A J Rees
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Quarterly journal of medicine     Volume:  81     ISSN:  0033-5622     ISO Abbreviation:  Q. J. Med.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-05-21     Completed Date:  1992-05-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401027     Medline TA:  Q J Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  929-36     Citation Subset:  IM    
Affiliation:
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Cytomegalovirus Infections / blood,  complications,  drug therapy*
Female
Fever / drug therapy
Ganciclovir / therapeutic use*
Humans
Immunocompromised Host*
Kidney Diseases / complications*,  immunology
Leukocyte Count / drug effects
Male
Middle Aged
Chemical
Reg. No./Substance:
82410-32-0/Ganciclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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